41296-66-6Relevant articles and documents
3-Aryl-4-methyl-2-quinolones Targeting Multiresistant Staphylococcus aureus Bacteria
Doleans-Jordheim, Anne,Veron, Jean-Baptiste,Fendrich, Olivier,Bergeron, Emmanuelle,Montagut-Romans, Adrien,Wong, Yung-Sing,Furdui, Bianca,Freney, Jean,Dumontet, Charles,Boumendjel, Ahcene
, p. 652 - 657 (2013/08/22)
The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus. We identified 3-aryl-4-methyl-2-quinolin-2-ones as compounds able to restore the activity of the NorA substrate, ciprofloxacin, against resistant S.aureus strains, and acting as efflux pump inhibitors (EPI). In particular, 5-hydroxy-7-methoxy-4-methyl-3-phenylquinolin-2-one (6c) presents both an EPI and an antimicrobial effect. Its efficacy and safety make it a potential candidate for further investigations.