N-[3-(Benzyloxy)-4-nitrophenyl]-N-(prop-2-en-1-yl)acetamide

Base Information

• Chemical Name: N-[3-(Benzyloxy)-4-nitrophenyl]-N-(prop-2-en-1-yl)acetamide
• CAS No.: 89102-05-6
• Molecular Formula: C18H18N2O4
• Molecular Weight: 326.352
• DSSTox Substance ID: DTXSID80556818
• Wikidata: Q82438516
• Mol file: 89102-05-6.mol

Synonyms:89102-05-6;DTXSID80556818;N-[3-(Benzyloxy)-4-nitrophenyl]-N-(prop-2-en-1-yl)acetamide

Chemical Property of N-[3-(Benzyloxy)-4-nitrophenyl]-N-(prop-2-en-1-yl)acetamide

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 326.12665706
• Heavy Atom Count: 24
• Complexity: 443

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)N(CC=C)C1=CC(=C(C=C1)[N+](=O)[O-])OCC2=CC=CC=C2

Technology Process of N-[3-(Benzyloxy)-4-nitrophenyl]-N-(prop-2-en-1-yl)acetamide

There total 6 articles about N-[3-(Benzyloxy)-4-nitrophenyl]-N-(prop-2-en-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(benzyloxy)-4-nitroacetanilide (89102-04-5) + allyl bromide (106-95-6) → N-(2-propenyl)-N-<3-(benzyloxy)-4-nitrophenyl>acetamide (89102-05-6)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

DOI:10.1016/S0040-4039(00)94004-8

Reference yield:

3-acetoxy-4-nitroacetanilide (89102-03-4) → N-(2-propenyl)-N-<3-(benzyloxy)-4-nitrophenyl>acetamide (89102-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃, methanol / 5 h / Ambient temperature

2: 98 percent / K₂CO₃, KI / dimethylformamide / 4 h / Ambient temperature

3: 83 percent / potassium tert-butoxide / dimethylformamide / 24 h / Ambient temperature

With methanol; potassium tert-butylate; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00256a036

Reference yield:

3-hydroxy-4-nitroacetanilide (712-34-5) → N-(2-propenyl)-N-<3-(benzyloxy)-4-nitrophenyl>acetamide (89102-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / K₂CO₃, KI / dimethylformamide / 4 h / Ambient temperature

2: 83 percent / potassium tert-butoxide / dimethylformamide / 24 h / Ambient temperature

With potassium tert-butylate; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00256a036

upstream raw materials:

3-(benzyloxy)-4-nitroacetanilide

allyl bromide

3-hydroxy-4-nitroacetanilide

3-acetamidophenyl acetate

Downstream raw materials:

7-(benzyloxy)-3-methyl-5-indole

N-Allyl-N-{3-benzyloxy-4-[N'-prop-(E)-ylidene-hydrazino]-phenyl}-acetamide

4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide