L-Leucine, N-[N-[N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]glycyl]-L-phenylalan yl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Leucine, N-[N-[N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]glycyl]-L-phenylalan yl]-, 1,1-dimethylethyl ester
CAS No.:89137-25-7
Molecular Formula:C₃₈H₄₆N₄O₇
Molecular Weight:670.806
Hs Code.:

Synonyms:

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Chemical Property of L-Leucine, N-[N-[N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]glycyl]-L-phenylalan yl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Leucine, N-[N-[N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]glycyl]-L-phenylalan yl]-, 1,1-dimethylethyl ester

There total 6 articles about L-Leucine, N-[N-[N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]glycyl]-L-phenylalan yl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35661-40-6
N-Fmoc L-Phe

: 89137-25-7
(S)-2-((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.5 h

2: 4-(aminomethyl)piperidine / CHCl₃ / 0.5 h

3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h

4: 4-(aminomethyl)piperidine / CHCl₃ / 0.5 h

5: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 4-Aminomethylpiperidine; N-ethyl-N,N-diisopropylamine; In chloroform;
DOI:10.1016/0040-4039(91)80176-7

Reference yield:

: 2748-02-9,13081-32-8
L-leucine tert-butyl ester hydrochloride

: 89137-25-7
(S)-2-((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.5 h

2: 4-(aminomethyl)piperidine / CHCl₃ / 0.5 h

3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h

4: 4-(aminomethyl)piperidine / CHCl₃ / 0.5 h

5: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 4-Aminomethylpiperidine; N-ethyl-N,N-diisopropylamine; In chloroform;
DOI:10.1016/0040-4039(91)80176-7

Reference yield:

: 28635-78-1
L-phenylalanyl-L-leucine tert-butyl ester

: 89137-25-7
(S)-2-((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h

2: 4-(aminomethyl)piperidine / CHCl₃ / 0.5 h

3: benzotriazolyloxy-tris(pyrrolidino)-phosphonium hexafluorophosphate, diisopropylethylamine / CHCl₃ / 0.17 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 4-Aminomethylpiperidine; N-ethyl-N,N-diisopropylamine; In chloroform;
DOI:10.1016/0040-4039(91)80176-7