LEUCINE ENKEPHALIN ACETATE SALT

Base Information

• Chemical Name: LEUCINE ENKEPHALIN ACETATE SALT
• CAS No.: 81678-16-2
• Molecular Formula: C30H41N5O9
• Molecular Weight: 615.684
• Mol file: 81678-16-2.mol

Synonyms:LEUCINE ENKEPHALIN ACETATE SALT;TYR-GLY-GLY-PHE-LEU ACETATE SALT;LEUCINE ENKEPHALIN SYNTHETIC ACETATE;(5-leucine)enkephalin acetate;Leucine Enkephalin hydrate acetate salt

Chemical Property of LEUCINE ENKEPHALIN ACETATE SALT

Chemical Property:

• PSA: 237.25000
• LogP: 2.19220
• Storage Temp.: −20°C

Purity/Quality:

95% ^*data from raw suppliers

[Leu5]-EnkephalinAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: [Leu5]-Enkephalin is a neurotransmitter used in molecular dynamics studies for the insertion of neurotransmitters into lipid bilayer membranes and their implication on membrane stability.

Technology Process of LEUCINE ENKEPHALIN ACETATE SALT

There total 14 articles about LEUCINE ENKEPHALIN ACETATE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ leucine enkephalin acetate (81678-16-2)

Guidance literature:

With ammonium formate; palladium diacetate; In water; N,N-dimethyl-formamide; for 2h; Ambient temperature; atmospheric pressure;

DOI:10.1016/S0040-4039(01)82959-2

Reference yield: 36.0%

N-benzyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine benzyl ester (69729-16-4) + acetic acid (64-19-7,77671-22-8) → leucine enkephalin acetate (81678-16-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 30h;

Reference yield:

Z-Tyr-Gly-Gly hydrazide (61543-55-3) → leucine enkephalin acetate (81678-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / TEA / dimethylformamide

2: 36 percent / H₂ / Pd/C / methanol / 30 h

With TEA; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

N-benzyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine benzyl ester

acetic acid

(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-tert-butoxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Z-Tyr-Gly-Gly hydrazide

Downstream raw materials:

L-phenylalanine

YG

L-Phe-Leu

tyrosylglycylglycine