1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one

Base Information

Chemical Name:1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
CAS No.:89144-77-4
Molecular Formula:C₁₇H₁₅ClN₂O
Molecular Weight:298.772
Hs Code.:
ChEMBL ID:CHEMBL195933
DSSTox Substance ID:DTXSID70563495
Nikkaji Number:J1.097.049K

Synonyms:CHEMBL195933;89144-77-4;DTXSID70563495;BDBM50164870;1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one;1-(3-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone;1-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone

Suppliers and Price of 1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:298.0872908
Heavy Atom Count:21
Complexity:409

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1C(CC(=N1)C2=CC=C(C=C2)Cl)C3=CC=CC=C3

Technology Process of 1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one

There total 6 articles about 1-[3-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 108-24-7
acetic anhydride

: 89144-74-1
3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazole

: 89144-77-4
1-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone

Guidance literature:: for 3h; Heating;
DOI:10.1021/je00036a038

Reference yield:

: 64-19-7,77671-22-8
acetic acid

: 956-02-5
4'-chlorochalcone

: 89144-77-4
1-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone

Guidance literature:: With hydrazine;
DOI:10.1016/j.bmcl.2005.02.055

Reference yield:

: 125324-48-3
4'-(p-chlorophenyl)-2-(3-methyl-5-oxo-2-pyrazolin-1-yl)thiazole

: 89144-77-4
1-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / piperidine / ethanol / 6 h / Heating

2: 68 percent / hydrazine hydrate / 6 h / Heating

With piperidine; hydrazine hydrate; In ethanol;