3-Methoxy-2-phenylimidazo[1,2-a]pyridine-5-carboxylic acid

Base Information

• Chemical Name: 3-Methoxy-2-phenylimidazo[1,2-a]pyridine-5-carboxylic acid
• CAS No.: 89192-95-0
• Molecular Formula: C₁₅H₁₂N₂O₃
• Molecular Weight: 268.272
• DSSTox Substance ID: DTXSID50528284
• Wikidata: Q82397765

Synonyms:3-methoxy-2-phenylimidazo[1,2-a]pyridine-5-carboxylic acid;89192-95-0;DTXSID50528284;AKOS015906088;3-methoxy-2-phenylimidazo[2,1-f]pyridine-5-carboxylic acid

Chemical Property of 3-Methoxy-2-phenylimidazo[1,2-a]pyridine-5-carboxylic acid

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 268.08479225
• Heavy Atom Count: 20
• Complexity: 357

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(N=C2N1C(=CC=C2)C(=O)O)C3=CC=CC=C3

Technology Process of 3-Methoxy-2-phenylimidazo[1,2-a]pyridine-5-carboxylic acid

There total 2 articles about 3-Methoxy-2-phenylimidazo[1,2-a]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-1H-imidazo<1,2-a>pyridinium-3-olate (25142-28-3) → 3-methoxy-2-phenylimidazo<1,2-a>pyrdine-5-carboxylic acid (89192-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 35 deg C, 10 min, 2.) 35 deg C, 15 min

2: 1.) THF, hexane, -70 deg C, 30 min, 2.) ether, -70 deg C

With sodium hydride;

DOI:10.1055/s-1983-30593

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 3-Methoxy-2-phenylimidazo<1,2-a>pyridine (89192-94-9) → 3-methoxy-2-phenylimidazo<1,2-a>pyrdine-5-carboxylic acid (89192-95-0)

Guidance literature:

Yield given. Multistep reaction; 1.) THF, hexane, -70 deg C, 30 min, 2.) ether, -70 deg C;

DOI:10.1055/s-1983-30593

Reference yield: 29.0%

3-methoxy-2-phenylimidazo<1,2-a>pyrdine-5-carboxylic acid (89192-95-0) + dimethyl sulfate (77-78-1) → 3-Methoxy-2-phenyl-imidazo[1,2-a]pyridine-5-carboxylic acid methyl ester

Guidance literature:

With potassium carbonate; In acetone; for 3h; Heating;

DOI:10.1002/jhet.5570330373

upstream raw materials:

carbon dioxide

3-Methoxy-2-phenylimidazo<1,2-a>pyridine

2-phenyl-1H-imidazo<1,2-a>pyridinium-3-olate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 89192-95-0 Imidazo[1,2-a]pyridine-5-carboxylic acid, 3-methoxy-2-phenyl-

Send

Send

Metric Ton KG G Pound L ML

Send

Send