N-ACETOXY-PHIP

Base Information

• Chemical Name: N-ACETOXY-PHIP
• CAS No.: 142784-27-8
• Molecular Formula: C₁₅H₁₄N₄O₂
• Molecular Weight: 282.302
• Mol file: 142784-27-8.mol

Synonyms:2H-Imidazo[4,5-b]pyridin-2-one,1,3-dihydro-1-methyl-6-phenyl-, O-acetyloxime (9CI); N-Acetoxy-PhIP

Chemical Property of N-ACETOXY-PHIP

Chemical Property:

• PSA: 69.04000
• LogP: 2.59830

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ACETOXY-PHIP

There total 1 articles about N-ACETOXY-PHIP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + N-Hydroxy-PhIP (124489-20-9) → N-(acetyloxy)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (142784-27-8)

Guidance literature:

In methanol; acetic acid; at 0 ℃; for 0.166667h;

DOI:10.1021/tx00047a005

Reference yield:

2’-deoxyguanosine-3’,5’-O-bisphosphate (16174-59-7) + N-(acetyloxy)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (142784-27-8) → N-(2'-deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-3',5'-bisphosphate

Guidance literature:

With potassium citrate; In ethanol; at 37 ℃; for 4h; pH=7;

DOI:10.1002/em.10060

Reference yield:

Leu-Gln-Lys-Cys-Pro-Tyr + N-(acetyloxy)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (142784-27-8) → 2-[(1-{2-{6-amino-2-[2-(2-amino-4-methyl-pentanoylamino)-4-carbamoyl-butyrylamino]-hexanoylamino}-3-[N-(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)aminosulfanyl]-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-(4-hydroxy-phenyl)-propionic acid

Guidance literature:

With potassium phosphate buffer; In methanol; formic acid; acetonitrile; at 37 ℃; for 1h; pH=7;

DOI:10.1016/j.fct.2003.11.012

upstream raw materials:

acetic anhydride

N-Hydroxy-PhIP

Downstream raw materials:

N-Hydroxy-PhIP

C₁₃⁽¹³⁾C₁₀H₂₃N₉O₄