1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexan-1-ol

Base Information

Chemical Name:1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexan-1-ol
CAS No.:89219-16-9
Molecular Formula:C₁₄H₁₆ClN₃O
Molecular Weight:277.754
Hs Code.:
DSSTox Substance ID:DTXSID70544224

Synonyms:89219-16-9;SCHEMBL9733626;DTXSID70544224;1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexan-1-ol

Suppliers and Price of 1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexan-1-ol

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:277.0981898
Heavy Atom Count:19
Complexity:309

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C(C1)N2C=NC=N2)(C3=CC=C(C=C3)Cl)O

Technology Process of 1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexan-1-ol

There total 6 articles about 1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 129501-16-2
2-bromo-1-(4-chlorophenyl)cyclohexanol

: 41253-21-8
sodium triazole

: 89219-16-9,100199-23-3,129501-01-5
trans-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexanol

Guidance literature:: In N,N-dimethyl acetamide; at 100 ℃; for 16h;
DOI:10.3987/COM-89-5280

Reference yield:

: 17380-84-6
4’-chloro-2,3,4,5-tetrahydro-1,1’-biphenyl

: 89219-16-9,100199-23-3,129501-01-5
trans-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 92.5 percent / N-bromoacetamide (NBA), H₂O / acetone / 4 h / Ambient temperature

2: 74 percent / N,N-dimethyl-acetamide / 16 h / 100 °C

With water; N-bromoacetamide; In N,N-dimethyl acetamide; acetone;
DOI:10.3987/COM-89-5280

Reference yield:

: 129500-92-1
2-hydroxy-cyclohexyl-1,2,4-triazole

: 89219-16-9,100199-23-3,129501-01-5
1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) trifluoroacetic anhydride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH₂Cl₂, room temperature, 2 h, 2.) from -65 deg C to 0 deg C, 1 h

2: tetrahydrofuran / 2 h / Ambient temperature

With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran;
DOI:10.3987/COM-89-5280