N-Ethyl-N-(4-methylphenyl)methanesulfonamide

Base Information

• Chemical Name: N-Ethyl-N-(4-methylphenyl)methanesulfonamide
• CAS No.: 89278-71-7
• Molecular Formula: C10H15NO2S
• Molecular Weight: 213.301
• DSSTox Substance ID: DTXSID10533016
• Wikidata: Q82406046
• Mol file: 89278-71-7.mol

Synonyms:89278-71-7;N-Ethyl-N-(4-methylphenyl)methanesulfonamide;SCHEMBL12407129;DTXSID10533016;AKOS011327124

Chemical Property of N-Ethyl-N-(4-methylphenyl)methanesulfonamide

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 213.08234989
• Heavy Atom Count: 14
• Complexity: 260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(C1=CC=C(C=C1)C)S(=O)(=O)C

Technology Process of N-Ethyl-N-(4-methylphenyl)methanesulfonamide

There total 5 articles about N-Ethyl-N-(4-methylphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C17H21NO2S + benzaldehyde (100-52-7) → p-cresol (106-44-5) + N-ethyl-N-p-tolylmethanesulfonamide (89278-71-7) + (E)-2-Phenyl-ethenesulfonic acid ethyl-p-tolyl-amide (89278-70-6)

Guidance literature:

for 3h; Product distribution;

DOI:10.1021/jo00182a016

Reference yield: 50.0%

C16H18BrNO2S + benzaldehyde (100-52-7) → 4-bromo-phenol (106-41-2) + N-ethyl-N-p-tolylmethanesulfonamide (89278-71-7) + N-Ethyl-N-p-tolyl-2-(p-bromophenoxy)-2-phenylethanesulfonamide (89278-79-5) + (E)-2-Phenyl-ethenesulfonic acid ethyl-p-tolyl-amide (89278-70-6)

Guidance literature:

for 3h; Product distribution;

DOI:10.1021/jo00182a016

Reference yield: 15.0%

C16H18ClNO2S (89278-85-3) + benzaldehyde (100-52-7) → N-ethyl-N-p-tolylmethanesulfonamide (89278-71-7) + N-Ethyl-N-tolyl-2-(p-chlorophenoxy)-2-phenylethanesulfonamide (89278-69-3) + N-Ethyl-N-p-tolyl-trans-styrenesulfonamide (89278-70-6) + 4-chloro-phenol (106-48-9,82344-39-6)

Guidance literature:

at -60 ℃; for 3h; Product distribution;

DOI:10.1021/jo00182a016

upstream raw materials:

methanesulfonyl chloride

N-ethyl-p-tolylamine

benzophenone

C₁₆H₁₈ClNO₂S