5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
CAS No.:89315-57-1
Molecular Formula:C₉H₉Cl₂N
Molecular Weight:202.083
Hs Code.:
ChEMBL ID:CHEMBL148913
DSSTox Substance ID:DTXSID70503770
Wikidata:Q82357805
Mol file:89315-57-1.mol

Synonyms:89315-57-1;5,8-dichloro-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 5,8-dichloro-1,2,3,4-tetrahydro-;5,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline;CHEMBL148913;SCHEMBL6188234;DTXSID70503770;AKOS024074216;FT-0717067;EN300-1232620

Suppliers and Price of 5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

PSA：12.03000
LogP:2.96790
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:201.0112047
Heavy Atom Count:12
Complexity:163

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC2=C(C=CC(=C21)Cl)Cl

Technology Process of 5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 5,8-Dichloro-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73075-59-9
5,8-dichloroisoquinoline

: 89315-57-1
5,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; at 25 ℃; under 3102.9 Torr;
DOI:10.1021/jm00179a007

Reference yield:

: 6361-23-5
2,5-dichloro-benzaldehyde

: 89315-57-1
5,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / benzene / Heating

2: concd. H₂SO₄ / 0.5 h / 140 - 150 °C

3: H₂ / PtO₂ / methanol / 25 °C / 3102.9 Torr

With sulfuric acid; hydrogen; platinum(IV) oxide; In methanol; benzene;
DOI:10.1021/jm00179a007

Reference yield:

: 34145-05-6
2,5-dichlorobenzyl alcohol

: 89315-57-1
5,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / MnO₂ / CH₂Cl₂ / 24 h

2: 100 percent / benzene / Heating

3: concd. H₂SO₄ / 0.5 h / 140 - 150 °C

4: H₂ / PtO₂ / methanol / 25 °C / 3102.9 Torr

With manganese(IV) oxide; sulfuric acid; hydrogen; platinum(IV) oxide; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00179a007