2,5-Dichlorobenzaldehyde

Base Information

• Chemical Name: 2,5-Dichlorobenzaldehyde
• CAS No.: 6361-23-5
• Molecular Formula: C7H4Cl2O
• Molecular Weight: 175.014
• Hs Code.: 29130000
• European Community (EC) Number: 228-832-1
• DSSTox Substance ID: DTXSID30212992
• Nikkaji Number: J81.204H
• Wikidata: Q72465434
• Mol file: 6361-23-5.mol

Synonyms:2,5-Dichlorobenzaldehyde;6361-23-5;Benzaldehyde, 2,5-dichloro-;2,5-dichloro-benzaldehyde;EINECS 228-832-1;MFCD00156140;2.5-Dichlorbenzaldehyd;2,5-dichlorbenzaldehyde;SCHEMBL42560;2,5-Dichlorobenzaldehyde, 96%;DTXSID30212992;AKOS003624846;AC-3246;CS-W017472;PS-3370;BP-10343;SY004807;AM20040926;D2814;FT-0610299;FT-0655877;EN300-57016;A24094;W-104894;F0001-1729;Z871801786

Chemical Property of 2,5-Dichlorobenzaldehyde

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Vapor Pressure: 0.0605mmHg at 25°C
• Melting Point: 231-233 °C
• Refractive Index: 1.6
• Boiling Point: 231.999 °C at 760 mmHg
• Flash Point: 96.588 °C
• PSA: 17.07000
• Density: 1.4 g/cm³
• LogP: 2.80590
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 173.9639201
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dichlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,C
• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)C=O)Cl

Technology Process of 2,5-Dichlorobenzaldehyde

There total 19 articles about 2,5-Dichlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,5-dichlorobenzyl alcohol (34145-05-6) → 2,5-dichloro-benzaldehyde (6361-23-5)

Guidance literature:

With potassium dichromate; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; for 4h; Ambient temperature;

DOI:10.1135/cccc19823077

Reference yield: 96.0%

m-Chlorobenzaldehyde (587-04-2) → 2,5-dichloro-benzaldehyde (6361-23-5)

Guidance literature:

With N-chloro-succinimide; palladium diacetate; silver trifluoroacetate; anthranilic acid; trifluoroacetic acid; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Sealed tube;

DOI:10.1021/jacs.6b11188

Reference yield: 90.0%

2-(2,5-dichlorophenyl)-1,3-dithiane → 2,5-dichloro-benzaldehyde (6361-23-5)

Guidance literature:

With eosin y; In water; acetonitrile; at 20 ℃; for 4h; Irradiation;

DOI:10.1016/j.tetlet.2019.151407

upstream raw materials:

2,5-dichlorobenzyl alcohol

N,N-dimethyl-formamide

1,2,4-Trichlorobenzene

α,α-Dibrom-2,5-dichlor-toluol

Downstream raw materials:

1-(2,5-dichloro-β-hydroxy-phenethyl)-pyridinium; bromide

1-(2,4-dichlorophenyl)pentane-1,4-dione

3,6-dichloro-2-nitro-benzaldehyde

ethyl 2-amino-8-chloro-4-(2,5-dichlorophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-thiochromeno[2,3-b]pyridine-3-carboxylate

Refernces

• 1、 Dharpure, Pankaj D.,Bhowmick, Anindita,Warghude, Prakash K.,Bhat, Ramakrishna G.. "Visible-light mediated facile dithiane deprotection under metal free conditions". . . Retrieved 2019/12/09.
• 2、 Ramazani, Ali,Khoobi, Mehdi,Sadri, Fariba,Tarasi, Roghayeh,Shafiee, Abbas,Aghahosseini, Hamideh,Joo, Sang Woo. "Efficient and selective oxidation of alcohols in water employing palladium supported nanomagnetic Fe3O4@hyperbranched polyethylenimine (Fe3O4@HPEI.Pd) as a new organic–inorganic hybrid nanocatalyst". . . Retrieved 2017/10/05.