Benzene, 1-[(1R,2R)-2-methylcyclopropyl]-4-(trifluoromethyl)-, rel-

Base Information

Chemical Name:Benzene, 1-[(1R,2R)-2-methylcyclopropyl]-4-(trifluoromethyl)-, rel-
CAS No.:89321-49-3
Molecular Formula:C11H11F3
Molecular Weight:200.204
Hs Code.:

Synonyms:

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Chemical Property of Benzene, 1-[(1R,2R)-2-methylcyclopropyl]-4-(trifluoromethyl)-, rel-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Benzene, 1-[(1R,2R)-2-methylcyclopropyl]-4-(trifluoromethyl)-, rel-

There total 8 articles about Benzene, 1-[(1R,2R)-2-methylcyclopropyl]-4-(trifluoromethyl)-, rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: Methanesulfonic acid (1S,2S)-2-(4-trifluoromethyl-phenyl)-cyclopropylmethyl ester

: 89321-49-3
trans-1-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 20 ℃; for 13h;
DOI:10.1139/cjc-77-5-6-1123

Reference yield:

: N-methoxy-N-methyl-trans-2-(4-(trifluoromethyl)phenyl)cyclopropanecarboxamide

: 89321-49-3
trans-1-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / aq. potassium tert-butoxide / diethyl ether / 16 h / 20 °C

2: 94 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

3: Et₃N / tetrahydrofuran / 0.5 h / -30 °C

4: 79 percent / LiBEt₃H / tetrahydrofuran / 13 h / 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; lithium triethylborohydride; triethylamine; In tetrahydrofuran; diethyl ether; 1: Hydrolysis / 2: Reduction / 3: Condensation / 4: Reduction;
DOI:10.1139/cjc-77-5-6-1123

Reference yield:

: 201164-14-9
(E)-N-methoxy-N-methyl-3-(4-(trifluoromethyl)phenyl)acrylamide

: 89321-49-3
trans-1-methyl-2-(4-(trifluoromethyl)phenyl)cyclopropane

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylsulfoxide / 1 h / 20 °C

1.2: 86 percent / dimethylsulfoxide / 6 h

2.1: 90 percent / aq. potassium tert-butoxide / diethyl ether / 16 h / 20 °C

3.1: 94 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4.1: Et₃N / tetrahydrofuran / 0.5 h / -30 °C

5.1: 79 percent / LiBEt₃H / tetrahydrofuran / 13 h / 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; lithium triethylborohydride; triethylamine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; 1.1: Metallation / 1.2: cyclopropanation / 2.1: Hydrolysis / 3.1: Reduction / 4.1: Condensation / 5.1: Reduction;
DOI:10.1139/cjc-77-5-6-1123