2-(2-Fluorophenyl)pyridine

Base Information

• Chemical Name: 2-(2-Fluorophenyl)pyridine
• CAS No.: 89346-48-5
• Molecular Formula: C11H8FN
• Molecular Weight: 173.19
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80431818
• Nikkaji Number: J1.567.399K
• Wikidata: Q82245797
• Mol file: 89346-48-5.mol

Synonyms:2-(2-fluorophenyl)pyridine;89346-48-5;2-fluorophenylpyridine;2-(2-fluoro-phenyl)pyridine;pyridine,2-(2-fluorophenyl)-;SCHEMBL1780998;DTXSID80431818;SVAOECAKLGBAEW-UHFFFAOYSA-N;MFCD09909420;AKOS006310239;AS-44476

Chemical Property of 2-(2-Fluorophenyl)pyridine

Chemical Property:

• Boiling Point: 263.0±15.0 °C(Predicted)
• PKA: 3.84±0.12(Predicted)
• PSA: 12.89000
• Density: 1.138±0.06 g/cm3(Predicted)
• LogP: 2.88770
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 173.064077422
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

2-(2-FLUOROPHENYL)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CC=CC=N2)F

Technology Process of 2-(2-Fluorophenyl)pyridine

There total 13 articles about 2-(2-Fluorophenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-pyridine (109-04-6) + o-fluorophenylboronic acid (1993-03-9) → 2-(2-fluorophenyl)pyridine (89346-48-5)

Guidance literature:

With trans-bis(triphenylphosphine)palladium dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃;

DOI:10.1002/chem.201902213

Reference yield: 66.0%

2-(2-Bromophenyl)pyridine (109306-86-7) → 2-(2-fluorophenyl)pyridine (89346-48-5)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 120 ℃; Reagent/catalyst; Temperature; Concentration;

DOI:10.1039/c3sc51876k

Reference yield: 62.0%

1-iodo-2-pyridinylbenzene (897440-10-7) → 2-(2-fluorophenyl)pyridine (89346-48-5)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 110 ℃;

DOI:10.1039/c3sc51876k

upstream raw materials:

pyridine

2-fluorobenzenediazonium tetrafluoroborate

2-bromo-pyridine

o-fluorophenylboronic acid

Downstream raw materials:

2-(2-(tert-butylthio)phenyl)pyridine

2-(2,6-difluorophenyl)pyridine

2-(2-pyridyl)thiophenol

2-(2-benzyl-6-fluorophenyl)pyridine