Pyrido[2,3-d]pyrimidin-4(1H)-one, 1-(4-methylphenyl)-2-(methylthio)-

Base Information

Chemical Name:Pyrido[2,3-d]pyrimidin-4(1H)-one, 1-(4-methylphenyl)-2-(methylthio)-
CAS No.:89374-66-3
Molecular Formula:C₁₅H₁₃N₃OS
Molecular Weight:283.354
Hs Code.:
DSSTox Substance ID:DTXSID10384186
Wikidata:Q82176152

Synonyms:Pyrido[2,3-d]pyrimidin-4(1H)-one, 1-(4-methylphenyl)-2-(methylthio)-;89374-66-3;1-(4-methylphenyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-4-one;Maybridge1_001745;Oprea1_673596;HMS546H07;DTXSID10384186;CCG-55386;SR-01000644412-1

Suppliers and Price of Pyrido[2,3-d]pyrimidin-4(1H)-one, 1-(4-methylphenyl)-2-(methylthio)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Pyrido[2,3-d]pyrimidin-4(1H)-one, 1-(4-methylphenyl)-2-(methylthio)-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:283.07793322
Heavy Atom Count:20
Complexity:404

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)N2C3=C(C=CC=N3)C(=O)N=C2SC

Technology Process of Pyrido[2,3-d]pyrimidin-4(1H)-one, 1-(4-methylphenyl)-2-(methylthio)-

There total 4 articles about Pyrido[2,3-d]pyrimidin-4(1H)-one, 1-(4-methylphenyl)-2-(methylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 89374-66-3
1-(Tolyl)-2-S-methylpyrido<3,2-e>thiouracil

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / 0.08 h / 40 °C

2: 60 percent / acetone / 0.5 h / 20 °C

3: 60 percent / Lithium hydride / dimethylformamide / Ambient temperature; the mixture stirred until homogeneous

4: Lithium hydride / 1) room temperature ca 40min.,DMF 2) add. methyl iodide,1h

With lithium hydride; In N,N-dimethyl-formamide; acetone;
DOI:10.1135/cccc19833315

Reference yield:

: 89374-20-9
2-Chloronicotinoyl Isothiocyanate

: 89374-66-3
1-(Tolyl)-2-S-methylpyrido<3,2-e>thiouracil

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / acetone / 0.5 h / 20 °C

2: 60 percent / Lithium hydride / dimethylformamide / Ambient temperature; the mixture stirred until homogeneous

3: Lithium hydride / 1) room temperature ca 40min.,DMF 2) add. methyl iodide,1h

With lithium hydride; In N,N-dimethyl-formamide; acetone;
DOI:10.1135/cccc19833315

Reference yield:

: 89374-27-6
1-(2-chloronicotinoyl)-3-(4-methylphenyl)thiourea

: 89374-66-3
1-(Tolyl)-2-S-methylpyrido<3,2-e>thiouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Lithium hydride / dimethylformamide / Ambient temperature; the mixture stirred until homogeneous

2: Lithium hydride / 1) room temperature ca 40min.,DMF 2) add. methyl iodide,1h

With lithium hydride; In N,N-dimethyl-formamide;
DOI:10.1135/cccc19833315