5-Bromo-8-chloro-1-phenyl-3H-2-benzazepine

Base Information

Chemical Name:5-Bromo-8-chloro-1-phenyl-3H-2-benzazepine
CAS No.:89376-32-9
Molecular Formula:C16H11BrClN
Molecular Weight:332.627
Hs Code.:
DSSTox Substance ID:DTXSID60533627

Synonyms:89376-32-9;5-Bromo-8-chloro-1-phenyl-3H-2-benzazepine;8-chloro-5-bromo-1-phenyl-3H-2-benzazepine;SCHEMBL11000415;DTXSID60533627;LNSQAJGEVZJVJA-UHFFFAOYSA-N

Suppliers and Price of 5-Bromo-8-chloro-1-phenyl-3H-2-benzazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of 5-Bromo-8-chloro-1-phenyl-3H-2-benzazepine

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:330.97634
Heavy Atom Count:19
Complexity:384

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C=C(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3)Br

Technology Process of 5-Bromo-8-chloro-1-phenyl-3H-2-benzazepine

There total 3 articles about 5-Bromo-8-chloro-1-phenyl-3H-2-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 81078-28-6
8-chloro-4,5-dibromo-4,5-dihydro-1-phenyl-3H-2-benzazepine

: 89376-32-9
5-bromo-8-chloro-1-phenyl-3H-2-benzazepine

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; tert-butyl alcohol; for 1.25h; Ambient temperature;
DOI:10.1021/jo00362a007

Reference yield:

: 101713-14-8
8-chloro-1-phenyl-3H-2-benzazepine hydrobromide

: 89376-32-9
5-bromo-8-chloro-1-phenyl-3H-2-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: Br₂ / CH₂Cl₂ / 19 h / Ambient temperature

2: 40percent aq. NaOH / dioxane / 2.5 h

With sodium hydroxide; bromine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo00362a007