3-Oxabicyclo[3.1.0]hexan-2-one, (1R,5S)-

Base Information

Chemical Name:3-Oxabicyclo[3.1.0]hexan-2-one, (1R,5S)-
CAS No.:89395-28-8
Molecular Formula:C5H6O2
Molecular Weight:98.1014
Hs Code.:

Synonyms:(1R,5S)-3-oxabicyclo<3.1.0>hexan-2-one;(1R,5S)-3-oxabicylo<3.1.0>hexan-2-one;(+)-(1R,5S)-3-oxabicyclo[3.1.0]hexan-2-one;(1R,5S)-3-Oxa-bicyclo[3.1.0]hexan-2-one;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Oxabicyclo[3.1.0]hexan-2-one, (1R,5S)-

Chemical Property:

PSA：26.30000
LogP:0.17930

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Oxabicyclo[3.1.0]hexan-2-one, (1R,5S)-

There total 1 articles about 3-Oxabicyclo[3.1.0]hexan-2-one, (1R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 826-34-6
dimethyl cis-cyclopropane-1,2-dicarboxylate

: 89395-28-8
(1R,5S)-3-oxabicyclo[3.1.0]hexan-2-one

Guidance literature:: Yield given. Multistep reaction; enzymatic;
DOI:10.1016/S0040-4039(00)60612-3

Reference yield:

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 89395-28-8
(1R,5S)-3-oxabicyclo[3.1.0]hexan-2-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 910630-48-7
(1R,2S)-cis-2-(tert-butyldiphenylsilyloxymethyl)-N-methoxy-N-methyl-1-cyclopropanecarboxamide

Guidance literature:: N,O-dimethylhydroxylamine*hydrochloride; With trimethylaluminum; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h;

(1R,5S)-3-oxabicyclo[3.1.0]hexan-2-one; In tetrahydrofuran; hexane; dichloromethane; at 20 ℃; for 5h;

tert-butylchlorodiphenylsilane; With 1H-imidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 30h;
DOI:10.1021/jm0603318

Reference yield:

: 89395-28-8
(1R,5S)-3-oxabicyclo[3.1.0]hexan-2-one

: 251444-03-8
(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: AlMe₃ / tetrahydrofuran; hexane / 0.5 h / 20 °C

1.2: CH₂Cl₂; tetrahydrofuran; hexane / 5 h / 20 °C

1.3: 356 mg / imidazole / dimethylformamide; CH₂Cl₂; tetrahydrofuran / 30 h / 20 °C

2.1: 95 percent / DIBAL-H / CH₂Cl₂; hexane / 1 h / -78 °C

With trimethylaluminum; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm0603318