3-(Tritylamino)propan-1-ol

Base Information

• Chemical Name: 3-(Tritylamino)propan-1-ol
• CAS No.: 89448-83-9
• Molecular Formula: C22H23NO
• Molecular Weight: 317.431
• DSSTox Substance ID: DTXSID20389364
• Nikkaji Number: J2.193.248E
• Wikidata: Q82185094
• Mol file: 89448-83-9.mol

Synonyms:3-(tritylamino)propan-1-ol;89448-83-9;1-Propanol, 3-[(triphenylmethyl)amino]-;3-(Tritylamino)-1-propanol;3-Hydroxy-N-trityl-1-propanamine;SCHEMBL2493446;DTXSID20389364;PTKCEDPIGMNZSL-UHFFFAOYSA-N;MFCD00586580;AKOS000520623;AS-64145;CS-0038870;3-[(TRIPHENYLMETHYL)AMINO]PROPAN-1-OL;W11924;SR-01000319244;SR-01000319244-1;BRD-K50590591-001-01-7

Chemical Property of 3-(Tritylamino)propan-1-ol

Chemical Property:

• PSA: 32.26000
• LogP: 4.34140
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 317.177964357
• Heavy Atom Count: 24
• Complexity: 292

Purity/Quality:

99% ^*data from raw suppliers

3-(Tritylamino)propan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NCCCO

Technology Process of 3-(Tritylamino)propan-1-ol

There total 9 articles about 3-(Tritylamino)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

trityl chloride (76-83-5) + propan-1-ol-3-amine (156-87-6) → 3-N-tritylamino-1-propanol (89448-83-9)

Guidance literature:

In tetrahydrofuran; 1.) 0 deg C, 4 h, 2.) RT, 2 d;

DOI:10.1002/jhet.5570300506

Reference yield:

Trt-βAla-OSu (58995-27-0) → 3-N-tritylamino-1-propanol (89448-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 15.75 h / 0 - 25 °C

2: LiAlH₄ / tetrahydrofuran / 12 h / Heating

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00335-0

Reference yield:

Triphenylmethylamin (5824-40-8) → 3-N-tritylamino-1-propanol (89448-83-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 45 percent / 30 h / 120 °C

2: 80 percent / sodium hydride / dioxane / 1.) RT, 10 min, 2.) reflux, 48 h

3: 84 percent / perchloric acid, acetic acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min, 3.) reflux, 60 h

4: 96 percent / thionyl chloride / heptane / 1.) RT, 10 min, 2.) reflux, 1 d

5: 83 percent / tetrahydrofuran / 1.) 0 deg C, 4 h, 2.) RT, 2 d

With thionyl chloride; perchloric acid; sodium hydride; acetic acid; In tetrahydrofuran; 1,4-dioxane; n-heptane;

DOI:10.1002/jhet.5570300506

upstream raw materials:

trityl chloride

propan-1-ol-3-amine

3-(trityl-amino)-N-(4-{[3-(trityl-amino)-propionyl]-[3-(trityl-amino)-propyl]-amino}-butyl)-N-[3-(trityl-amino)-propyl]-propionamide

Trt-βAla-OSu

Downstream raw materials:

3-(tritylamino)propyl methanesulfonate

N-Tritylazetidine

methoxytriphenylmethane

2-propyl-3-trityl-[1,3,2]oxazaphosphinane 2-oxide