3-Aminopropanol

Base Information

• Chemical Name: 3-Aminopropanol
• CAS No.: 156-87-6
• Molecular Formula: C3H9NO
• Molecular Weight: 75.1106
• Hs Code.: 2922.19
• European Community (EC) Number: 205-864-4
• NSC Number: 7766
• UN Number: 2735
• UNII: YMA7C44XGY
• DSSTox Substance ID: DTXSID0059746
• Nikkaji Number: J2.560G
• Wikipedia: 3-Amino-1-propanol
• Wikidata: Q223042
• ChEMBL ID: CHEMBL115530
• Mol file: 156-87-6.mol

Synonyms:3-amino-1-propanol;3-aminopropan-1-ol

Chemical Property of 3-Aminopropanol

Chemical Property:

• Appearance/Colour: clear colourless to very slightly yellow liquid
• Vapor Pressure: 2.1 mm Hg ( 20 °C)
• Melting Point: 10-12 °C(lit.)
• Refractive Index: n20/D 1.4598(lit.)
• Boiling Point: 187.5 °C at 760 mmHg
• PKA: pK1: 9.96(+1) (25°C)
• Flash Point: 79.4 °C
• PSA: 46.25000
• Density: 0.947 g/cm³
• LogP: 0.02780
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: water: soluble
• Water Solubility.: miscible
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 75.068413911
• Heavy Atom Count: 5
• Complexity: 16.4
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 22-34-20/21/22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amino Alcohols, Other
• Canonical SMILES: C(CN)CO
• Uses: Organic intermediate. 3-Amino-1-propanol is used in the production of anionic emulsifiers, nonionic polyethylene emulsions. Its salts such as hydrochloride, nitrate, sulfate, phosphate are used for the balanced curing action with selected textile resins. It is used as a starting material in the preparation of beta-lactam antibiotics, humectants for foods and cosmetics. It acts as a corrosion inhibitor and finds application in water treatment, metal treatment and absorption of carbon dioxide gas. 3-Amino-1-propanol was used in the synthesis of di-tert-butyl aminopropanol derivative.

Technology Process of 3-Aminopropanol

There total 46 articles about 3-Aminopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-Hydroxypropionitrile (109-78-4) → propan-1-ol-3-amine (156-87-6)

Guidance literature:

With ammonium hydroxide; hydrogen; silver nitrate; In methanol; at 45 - 75 ℃; under 1500.15 Torr; Temperature; High pressure; Inert atmosphere; Autoclave;

Reference yield: 95.0%

3-(benzylamino)propan-1-ol (4720-29-0) → propan-1-ol-3-amine (156-87-6)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 0.166667h; Heating;

Reference yield: 93.8%

3-benzyloxypropionitrile (6328-48-9) → propan-1-ol-3-amine (156-87-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In dichloromethane; water; at 40 ℃; for 4h; under 3375.34 Torr; Temperature; Pressure; Solvent; Autoclave;

upstream raw materials:

PYRIMIDINE

3-amino-propionic acid ethyl ester

2-cyanoethyl ether

3-nitropropan-1-ol

Downstream raw materials:

3-[(2-hydroxyethyl)amino]propanol

1-(3-hydroxypropyl)pyrrolidin-2-one

panthenol

2-(3-bromopropyl)isoindole-1,3-dione

Refernces

The investigation of stereogenic properties of cyclotriphosphazene derivatives with two different chiral centres

10.1016/j.poly.2011.03.028

The research investigates the stereogenic properties of cyclotriphosphazene derivatives with two different chiral centers. The purpose is to explore the geometric isomers and racemic forms of these compounds, which have potential applications in various fields due to their chirality. Key chemicals used include hexachlorocyclotriphosphazene (N3P3Cl6) and gem-disubstituted cyclotriphosphazene derivatives (N3P3Cl4X2, where X = Ph, PhS, PhNH), which were reacted with N-methyl-1,3-propanediamine and 3-amino-1-propanol to produce compounds with two different stereogenic phosphorus atoms. The geometric isomers were separated and characterized using techniques such as X-ray crystallography, 31P and 1H NMR spectroscopy, and chiral HPLC. The study confirmed that these compounds exist as cis and trans geometric isomers and as two different racemic isomers. The enantiomers of the racemic compounds were analyzed using a chiral solvating agent (CSA) and chiral HPLC methods developed for this study. The conclusions highlight the successful synthesis and characterization of these chiral cyclotriphosphazene compounds, providing insights into their stereogenic properties and potential uses in chiral chemistry.

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