4,7-Dimethoxy-1,3-diphenyl-2-benzofuran

Base Information

• Chemical Name: 4,7-Dimethoxy-1,3-diphenyl-2-benzofuran
• CAS No.: 89449-71-8
• Molecular Formula: C22H18O3
• Molecular Weight: 330.383
• DSSTox Substance ID: DTXSID70527532
• Wikidata: Q82396739

Synonyms:89449-71-8;4,7-Dimethoxy-1,3-diphenylisobenzofuran;4,7-Dimethoxy-1,3-diphenyl-2-benzofuran;DTXSID70527532

Chemical Property of 4,7-Dimethoxy-1,3-diphenyl-2-benzofuran

Chemical Property:

• XLogP3: 5.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 330.125594432
• Heavy Atom Count: 25
• Complexity: 376

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C2=C(OC(=C12)C3=CC=CC=C3)C4=CC=CC=C4)OC

Technology Process of 4,7-Dimethoxy-1,3-diphenyl-2-benzofuran

There total 3 articles about 4,7-Dimethoxy-1,3-diphenyl-2-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,7-dimethoxy-phthalide (64019-78-9) → 4,7-Dimethoxy-1,3-diphenylisobenzofuran (89449-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / N-bromosuccinimide / dibenzoyl peroxide / CCl₄ / 0.75 h / Heating

2: 1.) magnesium / 1.) ether, 2.) benzene, reflux, 3 h

With N-Bromosuccinimide; magnesium; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1055/s-1983-30608

Reference yield:

bromobenzene (108-86-1,52753-63-6) + 3-Bromo-4,7-dimethoxyphthalide (89449-77-4) → 4,7-Dimethoxy-1,3-diphenylisobenzofuran (89449-71-8)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) ether, 2.) benzene, reflux, 3 h;

DOI:10.1055/s-1983-30608

Reference yield:

3-Bromo-4,7-dimethoxyphthalide (89449-77-4) + phenylmagnesium bromide (100-58-3) → 4,7-Dimethoxy-1,3-diphenylisobenzofuran (89449-71-8)

Guidance literature:

In diethyl ether; benzene; 25 deg C, 20 min; reflux, 15 min;

DOI:10.1016/0040-4039(96)01299-3

upstream raw materials:

bromobenzene

3-Bromo-4,7-dimethoxyphthalide

phenylmagnesium bromide

4,7-dimethoxy-phthalide

Downstream raw materials:

dibenzoyl-2,3 dimethoxy-1,4 benzene

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