1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one

Base Information

Chemical Name:1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one
CAS No.:96449-69-3
Deprecated CAS:116041-16-8
Molecular Formula:C12H15NO2
Molecular Weight:205.257
Hs Code.:2933790090
European Community (EC) Number:870-013-1
DSSTox Substance ID:DTXSID50914502
Nikkaji Number:J1.336.352H
Mol file:96449-69-3.mol

Synonyms:1-benzyl-4-(hydroxymethyl)pyrrolidin-2-one;96449-69-3;4-(Hydroxymethyl)-1-benzylpyrrolidin-2-one;2-Pyrrolidinone, 4-(hydroxymethyl)-1-(phenylmethyl)-;WEB-1868;1-Benzyl-4-(hydroxymethyl)-2-pyrrolidone;Web 1868;MFCD10003985;(+-)-1-Benzyl-4-hydroxymethylpyrrolidin-2-one;1-Benzyl-4-hydroxymethyl-pyrrolidin-2-one;1-benzyl-4-(hydroxymethyl)-2-pyrrolidinone;SCHEMBL3240700;DTXSID50914502;WDA44969;1-Benzyl-5-oxo-3-pyrrolidinemethanol;AKOS013528574;AB56109;AM804622;AS-41333;SY030075;1-benzyl-4-hydroxymethyl-pyrrolidine-2-one;CS-0038287;FT-0706135;EN300-86026

Suppliers and Price of 1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one
500mg
$ 350.00

Synthonix
1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one 95+%
10g
$ 880.00

Matrix Scientific
4-(Hydroxymethyl)-1-benzylpyrrolidin-2-one 97%
1g
$ 323.00

Crysdot
1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one 97%
5g
$ 555.00

Chemenu
1-BENZYL-4-(HYDROXYMETHYL)PYRROLIDIN-2-ONE 95+%
5g
$ 519.00

Atlantic Research Chemicals
4-(Hydroxymethyl)-1-benzylpyrrolidin-2-one 95%
1gm:
$ 123.71

American Custom Chemicals Corporation
1-BENZYL-4-(HYDROXYMETHYL)PYRROLIDIN-2-ONE 95.00%
5MG
$ 500.29

Alichem
1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one
10g
$ 697.84

Alichem
1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one
5g
$ 577.20

AK Scientific
1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one
2.5g
$ 559.00

Total 27 raw suppliers

Chemical Property of 1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one

Chemical Property:

Vapor Pressure:1.68E-07mmHg at 25°C
Boiling Point:411.3°Cat760mmHg
Flash Point:202.5°C
PSA：40.54000
Density:1.185g/cm³
LogP:0.96530
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:205.110278721
Heavy Atom Count:15
Complexity:224

Purity/Quality:

99%, ^*data from raw suppliers

1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CN(C1=O)CC2=CC=CC=C2)CO

Technology Process of 1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one

There total 5 articles about 1-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 51535-00-3
methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate

: 96449-69-3
1-benzyl-4-(hydroxymethyl)-2-pyrrolidinone

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.114

Reference yield:

: 5733-86-8
1-benzyl-5-oxopyrrolidine-3-carboxylic acid

: 96449-69-3
1-benzyl-4-(hydroxymethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride

2: sodium tetrahydroborate / isopropyl alcohol

With sodium tetrahydroborate; thionyl chloride; In isopropyl alcohol;
DOI:10.1021/acs.joc.7b02150

Reference yield:

: 617-52-7
Dimethyl itakonate

: 96449-69-3
1-benzyl-4-(hydroxymethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 21 h / 90 °C

2: sodium tetrahydroborate; methanol / water / 4 h / 0 - 5 °C

With methanol; sodium tetrahydroborate; In water;