3-Pyridazinecarboxylic acid, 5-cyano-1,6-dihydro-4-methyl-6-oxo-1-phenyl-, ethyl ester

Base Information

• Chemical Name: 3-Pyridazinecarboxylic acid, 5-cyano-1,6-dihydro-4-methyl-6-oxo-1-phenyl-, ethyl ester
• CAS No.: 89516-24-5
• Molecular Formula: C15H13N3O3
• Molecular Weight: 283.287
• Mol file: 89516-24-5.mol

Synonyms:5-Cyano-4-methyl-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester;N-phenyl-3-carboethoxy-4-methyl-5-cyanopyridazin-6-one;ethyl 5-cyano-1,6-dihydro-4-methyl-6-oxo-1-phenylpyridazine-3-carboxylate;

Chemical Property of 3-Pyridazinecarboxylic acid, 5-cyano-1,6-dihydro-4-methyl-6-oxo-1-phenyl-, ethyl ester

Chemical Property:

• PSA: 84.98000
• LogP: 1.58928

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridazinecarboxylic acid, 5-cyano-1,6-dihydro-4-methyl-6-oxo-1-phenyl-, ethyl ester

There total 12 articles about 3-Pyridazinecarboxylic acid, 5-cyano-1,6-dihydro-4-methyl-6-oxo-1-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl (2E)-3-oxo-2-(2-phenylhydrazinylidene)butanoate (60083-22-9) + ethyl 2-cyanoacetate (105-56-6) → ethyl 5-cyano-4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate (89516-24-5)

Guidance literature:

With ammonium acetate; In acetic acid; at 70 ℃; for 0.0155556h; irradiation in microwave oven;

DOI:10.1080/00397919708004105

Reference yield: 85.0%

ethyl (Z)-3-oxo-2-(2-phenylhydrazono)butanoate (60083-15-0) + ethyl 2-cyanoacetate (105-56-6) → ethyl 5-cyano-4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate (89516-24-5)

Guidance literature:

With ammonium acetate; In acetic acid; benzene; at 160 ℃; for 7h;

Reference yield: 82.0%

2-Cyan-3-methyl-glutaconsaeure-ethylester (5832-69-9) + benzene diazonium chloride (100-34-5) → ethyl 5-cyano-4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate (89516-24-5)

Guidance literature:

With sodium acetate; In ethanol; for 0.166667h;

DOI:10.1055/s-1984-30732

upstream raw materials:

2-Cyan-3-methyl-glutaconsaeure-ethylester

benzene diazonium chloride

1-cyano-1,3-diethoxycarbonyl-2-methyl-1-propene

ethyl 5-amino-3,4-dihydro-4-oxo-3-phenylthieno<3,4-d>pyridazine-1-carboxylate

Downstream raw materials:

ethyl 5-amino-7-(m-bromophenyl)-6-cyano-3,4-dihydro-4-oxo-3-phenylphthalazine-1-carboxylate

ethyl 5-amino-6-cyano-3,4-dihydro-4-oxo-3,7-diphenylphthalazine-1-carboxylate

5-Amino-6-cyano-7-(4-methoxy-phenyl)-4-oxo-3-phenyl-3,4-dihydro-phthalazine-1-carboxylic acid ethyl ester

ethyl 5-amino-7-(o-chlorophenyl)-6-cyano-3,4-dihydro-4-oxo-3-phenylphthalazine-1-carboxylate