N-(2-chloro-4-nitrophenyl)formamide

Base Information

• Chemical Name: N-(2-chloro-4-nitrophenyl)formamide
• CAS No.: 16135-32-3
• Molecular Formula: C7H5 Cl N2 O3
• Molecular Weight: 200.5792
• Mol file: 16135-32-3.mol

Synonyms:Formanilide,2'-chloro-4'-nitro- (8CI); 2-Chloro-4-nitroformanilide;2'-Chloro-4'-nitroformanilide; NSC 88974

Chemical Property of N-(2-chloro-4-nitrophenyl)formamide

Chemical Property:

• Vapor Pressure: 3.8E-07mmHg at 25°C
• Boiling Point: 416.5°Cat760mmHg
• Flash Point: 205.7°C
• Density: 1.542g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-chloro-4-nitrophenyl)formamide

There total 3 articles about N-(2-chloro-4-nitrophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Chloro-4-nitroaniline (121-87-9) + formyl acetic anhydride (2258-42-6) → 2-chloro-4-nitroformanilide (16135-32-3)

Guidance literature:

In tetrahydrofuran; at 25 ℃; for 3h;

DOI:10.1016/S0040-4039(00)87603-0

Reference yield: 95.0%

formic acid (64-18-6) + 2-Chloro-4-nitroaniline (121-87-9) → 2-chloro-4-nitroformanilide (16135-32-3)

Guidance literature:

With 4-(trifluoromethyl)benzoic anhydride; ytterbium(III) triflate; In dichloromethane; water; for 6h; Heating;

Reference yield:

→ 2-chloro-4-nitroformanilide (16135-32-3)

Guidance literature:

2-Chlor-4-nitroanilin, CO, Na-Methylat, MeOH, Erwaermen (Anfangs-p(CO): 140atm.);

upstream raw materials:

2-Chloro-4-nitroaniline

formyl acetic anhydride

formic acid

Downstream raw materials:

N-methyl-2-chloro-4-nitroaniline

2-Chlor-4-nitro-phenyl-isocyaniddichlorid

Refernces

• 1、 Krishnamurthy, S.. "A HIGHLY EFFICIENT AND GENERAL N-MONOMETHYLATION OF FUNCTIONALIZED PRIMARY AMINES VIA FORMYLATION -- BORANE:METHYL SULFIDE REDUCTION". . p. 3315 - 3318. Retrieved 2007/10/02.