2,6-Pyridinedimethanol, 4-methoxy-

Base Information

• Chemical Name: 2,6-Pyridinedimethanol, 4-methoxy-
• CAS No.: 89561-22-8
• Molecular Formula: C8H11NO3
• Molecular Weight: 169.18
• DSSTox Substance ID: DTXSID10445302

Synonyms:2,6-Pyridinedimethanol, 4-methoxy-;89561-22-8;[6-(HYDROXYMETHYL)-4-METHOXYPYRIDIN-2-YL]METHANOL;2,6-bis(hydroxymethyl)-4-methoxypyridine;SCHEMBL6990127;DTXSID10445302;IQTQJYVOZRRCFV-UHFFFAOYSA-N;4-methoxy-2,6-bis(hydroxymethyl)pyridine;EN300-7829005;J-400185;Z1255404772

Chemical Property of 2,6-Pyridinedimethanol, 4-methoxy-

Chemical Property:

• PSA: 62.58000
• LogP: 0.07480
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 169.07389321
• Heavy Atom Count: 12
• Complexity: 120

Purity/Quality:

4-methoxy-2,6-Pyridinedimethanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC(=C1)CO)CO

Technology Process of 2,6-Pyridinedimethanol, 4-methoxy-

There total 9 articles about 2,6-Pyridinedimethanol, 4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethyl 4-methoxypyridine-2,6-dicarboxylate (19872-93-6) → 2,6-bis(hydroxymethyl)-4-methoxypyridine (89561-22-8)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 26h; Reflux;

DOI:10.1016/j.bmc.2020.115816

Reference yield:

dimethyl 4-methoxypyridine-2,6-dicarboxylate (19872-93-6) + water (7732-18-5) → 2,6-bis(hydroxymethyl)-4-methoxypyridine (89561-22-8)

Guidance literature:

With sodium borohydrid; In ethanol; ethyl acetate;

Reference yield:

chelidamic acid (138-60-3) → 2,6-bis(hydroxymethyl)-4-methoxypyridine (89561-22-8)

Guidance literature:

Multi-step reaction with 4 steps

1: PCl₅ / CHCl₃ / Heating

3: methanol / Heating

4: NaBH₄ / ethanol / Heating

With sodium tetrahydroborate; phosphorus pentachloride; In methanol; ethanol; chloroform; 1: Chlorination / 2: Esterification / 3: Substitution / 4: Reduction;

DOI:10.1021/jm990211i

upstream raw materials:

dimethyl 4-methoxypyridine-2,6-dicarboxylate

4-chloropyridine-2,6-dicarbonyl dichloride

dimethyl 4-chloro-2,6-pyridinedicarboxylate

chelidamic acid

Downstream raw materials:

C₆₄H₇₈N₈O₁₀S₄

[15-methoxy-3,11-bis-(toluene-4-sulfonyl)-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-7-yl]-phosphonic acid diethyl ester

15-methoxy-3,11-bis-(toluene-4-sulfonyl)-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-triene

4-methoxy-2,6-bis[(p-tolylsulfonyl)oxymethyl]pyridine

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