Technology Process of Benzenepropanoic acid, a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,
(1,1-dimethylethyl)dimethylsilyl ester, (S)-
There total 1 articles about Benzenepropanoic acid, a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,
(1,1-dimethylethyl)dimethylsilyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
for 21h;
Ambient temperature;
DOI:10.1021/jo982376p
- Guidance literature:
-
Multi-step reaction with 6 steps
1: (COCl)2, DMF / CH2Cl2 / 2 h
2: DMAP / CH2Cl2 / 14 h
3: TBAF / tetrahydrofuran / 0.33 h / 0 °C
4: 72 percent / Et3N / CCl4; acetonitrile / 18 h / -10 °C
5: H2 / Pd(OH)2/C / ethanol / 1.5 h
6: acetonitrile
With
dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine; N,N-dimethyl-formamide;
palladium dihydroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo952074c
- Guidance literature:
-
Multi-step reaction with 7 steps
1: (COCl)2, DMF / CH2Cl2 / 2 h
2: DMAP / CH2Cl2 / 14 h
3: TBAF / tetrahydrofuran / 0.33 h / 0 °C
4: 72 percent / Et3N / CCl4; acetonitrile / 18 h / -10 °C
5: H2 / Pd(OH)2/C / ethanol / 1.5 h
6: acetonitrile
7: 1.) t-BuNH2, 2.) Dowex-Li+ / Heating
With
dmap; oxalyl dichloride; Dowex-Li+; tetrabutyl ammonium fluoride; hydrogen; tert-butylamine; triethylamine; N,N-dimethyl-formamide;
palladium dihydroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo952074c
