4-Hydroxyhippuric acid

Base Information

Chemical Name:4-Hydroxyhippuric acid
CAS No.:2482-25-9
Molecular Formula:C9H9NO4
Molecular Weight:195.175
Hs Code.:2924299090
European Community (EC) Number:822-262-2
UNII:4E2MH5995F
DSSTox Substance ID:DTXSID50179518
Nikkaji Number:J628.629A
Wikidata:Q27139257
Metabolomics Workbench ID:42473
ChEMBL ID:CHEMBL500596
Mol file:2482-25-9.mol

Synonyms:4-hydroxybenzoylglycine;4-hydroxyhippuric acid;N-(4-hydroxybenzoyl)glycine;p-hydroxyhippuric acid

Suppliers and Price of 4-Hydroxyhippuric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-HydroxyhippuricAcid
25mg
$ 55.00

Matrix Scientific
2-[(4-Hydroxyphenyl)formamido]acetic acid 95%+
1g
$ 281.00

Matrix Scientific
2-[(4-Hydroxyphenyl)formamido]acetic acid 95%+
5g
$ 928.00

Matrix Scientific
2-[(4-Hydroxyphenyl)formamido]acetic acid 95%+
2.500g
$ 612.00

Crysdot
2-(4-Hydroxybenzamido)aceticacid 97%
25g
$ 1725.00

Crysdot
2-(4-Hydroxybenzamido)aceticacid 97%
10g
$ 717.00

Crysdot
2-(4-Hydroxybenzamido)aceticacid 97%
5g
$ 422.00

Chem-Impex
p-Hydroxyhippuricacid,99%(titration) 99%(titration)
250MG
$ 44.80

Chem-Impex
p-Hydroxyhippuricacid,99%(titration) 99%(titration)
1G
$ 72.80

Chem-Impex
-Hydroxyhippuric acid ≥ 99% (titration)
25G
$ 960.00

Total 23 raw suppliers

Chemical Property of 4-Hydroxyhippuric acid

Chemical Property:

Vapor Pressure:1.77E-11mmHg at 25°C
Melting Point:240 °C (decomp)
Refractive Index:1.604
Boiling Point:516.2 °C at 760 mmHg
PKA:3.57±0.10(Predicted)
Flash Point:266 °C
PSA：86.63000
Density:1.4g/cm³
LogP:0.59750
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:-0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:195.05315777
Heavy Atom Count:14
Complexity:221

Purity/Quality:

97% ^*data from raw suppliers

4-HydroxyhippuricAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)NCC(=O)O)O
Uses Derivative of 4-Hydroxyhippuric Acid used as a probe for estimating the activities of organic anion transporter 3 (OAT3) and multidrug resistance-associated protein 4 (MRP4) which mediate the efflux of organic anion from the brain and heart in mouse.

Technology Process of 4-Hydroxyhippuric acid

There total 10 articles about 4-Hydroxyhippuric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 28141-24-4
4-hydroxybenzoyl chloride

: 56-40-6,18875-39-3,25718-94-9
glycine

: 2482-25-9
4-hydroxyhippuric acid

Guidance literature:: In water;
DOI:10.1134/S1070363215090261

Reference yield: 77.0%

: 62086-71-9
(4-methoxybenzoylamino)acetic acid methyl ester

: 2482-25-9
4-hydroxyhippuric acid

Guidance literature:

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 2482-25-9
4-hydroxyhippuric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / triethylamine / toluene / 2 h / Heating

2: 60 percent / SOCl₂ / CH₂Cl₂ / 3 h / Heating

3: 2) ethyl acetate / 1) methylene chloride, 30 min, reflux, 2) THF

With thionyl chloride; ethyl acetate; triethylamine; In dichloromethane; toluene;