Chemical Property of Diethylene glycol
Chemical Property:
- Appearance/Colour:colorless liquid
- Vapor Pressure:0.01 mm Hg ( 20 °C)
- Melting Point:-10 °C(lit.)
- Refractive Index:n20/D 1.447(lit.)
- Boiling Point:245.689 °C at 760 mmHg
- PKA:14.03±0.10(Predicted)
- Flash Point:143.333 °C
- PSA：49.69000
- Density:1.106 g/cm3
- LogP:-1.01240
- Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
- Sensitive.:Hygroscopic
- Solubility.:H2O: 50 mg/mL at 20 °C, clear, colorless
- Water Solubility.:SOLUBLE
- XLogP3:-1.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:106.062994177
- Heavy Atom Count:7
- Complexity:26.1
- Purity/Quality:
-
99.0%Min *data from raw suppliers
Diethylene Glycol *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
T,
Xi
- Hazard Codes:Xn,T,Xi
- Statements:
22
- Safety Statements:
46
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Classes -> Ethylene Glycols
- Canonical SMILES:C(COCCO)O
- Inhalation Risk:A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
- Effects of Short Term Exposure:The substance may cause effects on the kidneys. This may result in kidney impairment. Ingestion could cause effects on the central nervous system and liver. Ingestion could cause death.
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Chemical Properties
Diethylene glycol (DEG) is a clear, practically odorless, colorless, and viscous liquid with a sweetish taste. It is soluble in water and ethanol.
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Industrial Uses
DEG has numerous industrial applications, including use as an antifreeze agent, chemical intermediary, solvent, heat transfer fluid, brake fluid, cement processing, and lubricant.
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Toxicity
While DEG itself has low toxicity, it undergoes biotransformation in the liver, leading to the production of highly toxic metabolites such as 2-hydroxyethoxyacetic (2-HEAA) and diglycolic acid (DGA). These metabolites can persist in the body for a long time and cause acute toxic syndrome, resulting in renal failure due to cortical tubular degeneration and proximal tubular necrosis.
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Adulteration in Pharmaceuticals
DEG has been mistakenly used as a less expensive alternative to glycerin in pharmaceutical preparations, resulting in fatal poisonings. Clinical manifestations of DEG poisoning include hepatotoxicity, metabolic acidosis, and acute kidney injury.
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Analytical Detection
Various analytical methods, including gas chromatography with flame ionization detection (GC-FID) and ultra-performance liquid chromatography鈥搕ime of flight mass spectrometry (UHPLC-MS), have been developed to detect DEG in pharmaceuticals, healthcare products, alcoholic beverages, toothpaste, food items, and even human plasma.
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Textile Printing
DEG has been utilized in digital inkjet printing technology for textile printing. Addition of DEG can improve the printability of reactive dye inks, change the aggregation of dye molecules, inhibit formation of satellite droplets, and enhance color strength and brightness in printed fabrics.
