2-Butyl-4-methylpyridine

Base Information

• Chemical Name: 2-Butyl-4-methylpyridine
• CAS No.: 6304-31-0
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• Hs Code.: 2933399090
• European Community (EC) Number: 228-609-9
• NSC Number: 42634
• UNII: FE3QPV8LRQ
• DSSTox Substance ID: DTXSID5074349
• Nikkaji Number: J206.887G
• Wikidata: Q82002719
• Mol file: 6304-31-0.mol

Synonyms:2-Butyl-4-methylpyridine;6304-31-0;Pyridine, 2-butyl-4-methyl-;EINECS 228-609-9;NSC-42634;NSC42634;butyl-4-methylpyridine;FE3QPV8LRQ;4-Picoline, 2-butyl-;2-n-butyl-4-methylpyridine;Pyridine, 2-butyl-4-methyl;Pyridine,2-butyl-4-methyl-;SCHEMBL645891;DTXSID5074349;NSC 42634

Chemical Property of 2-Butyl-4-methylpyridine

Chemical Property:

• Vapor Pressure: 0.209mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 216.1 °C at 760 mmHg
• Flash Point: 79.6 °C
• PSA: 12.89000
• Density: 0.905 g/cm³
• LogP: 2.73260
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 149.120449483
• Heavy Atom Count: 11
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC1=NC=CC(=C1)C

Technology Process of 2-Butyl-4-methylpyridine

There total 5 articles about 2-Butyl-4-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2-Butyl-4-methyl-2H-pyridine-1-carboxylic acid ethyl ester (132819-57-9) → 2-n-butyl-4-methylpyridine (6304-31-0) + ethyl methyl carbonate (623-53-0,872521-98-7)

Guidance literature:

With sodium methylate; In methanol; at 18 ℃; anodic oxidation (graphite-rod electrodes);

Reference yield: 10.0%

thirane (420-12-2) + picoline (108-89-4) + n-butyllithium (109-72-8,29786-93-4) → 2-n-butyl-4-methylpyridine (6304-31-0) + 3-(pyridin-4'-yl)propanethiol (26847-63-2) + C16H20N2S2 (1265870-04-9)

Guidance literature:

picoline; n-butyllithium; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - -10 ℃; Inert atmosphere;

thirane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2010.11.003

Reference yield:

picoline (108-89-4) → 2-n-butyl-4-methylpyridine (6304-31-0) + 4,4'-dimethyl-2,2'-bipyridines (1134-35-6)

Guidance literature:

With n-butyllithium; diethyl ether;

DOI:10.1021/jo01359a022 DOI:10.1021/ja01188a503

upstream raw materials:

picoline

2,4-lutidine

2-Butyl-4-methyl-2H-pyridine-1-carboxylic acid ethyl ester

n-valeryl chloride

Downstream raw materials:

2-(4-methyl-[2]pyridyl)-1-phenyl-pentan-1-one