5,6-Dichloro-2-phenyl-1H-benzimidazole

Base Information

• Chemical Name: 5,6-Dichloro-2-phenyl-1H-benzimidazole
• CAS No.: 90300-22-4
• Molecular Formula: C13H8Cl2N2
• Molecular Weight: 263.126
• DSSTox Substance ID: DTXSID00523441
• Nikkaji Number: J2.327.760C
• Wikidata: Q82389529
• Mol file: 90300-22-4.mol

Synonyms:5,6-Dichloro-2-phenyl-1H-benzimidazole;90300-22-4;SCHEMBL9000174;DTXSID00523441;AKOS005266193;5,6-dichloro-2-phenyl-1 h -benzimidazole

Chemical Property of 5,6-Dichloro-2-phenyl-1H-benzimidazole

Chemical Property:

• PSA: 28.68000
• LogP: 4.53670
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 262.0064537
• Heavy Atom Count: 17
• Complexity: 268

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC3=CC(=C(C=C3N2)Cl)Cl

Technology Process of 5,6-Dichloro-2-phenyl-1H-benzimidazole

There total 20 articles about 5,6-Dichloro-2-phenyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + benzaldehyde (100-52-7) → 5,6-dichloro-2-phenyl-1H-benzo[d]imidazole (90300-22-4)

Guidance literature:

With air; TZ-HCP₁D polymer; In ethanol; at 20 ℃; for 1.8h; Irradiation;

DOI:10.1039/d0gc03719b

Reference yield: 84.0%

4,5-dichloro-2-iodobenzenamine (220185-63-7) + benzaldehyde (100-52-7) → 5,6-dichloro-2-phenyl-1H-benzo[d]imidazole (90300-22-4)

Guidance literature:

With ammonium hydroxide; 8-quinolinol; caesium carbonate; nickel dichloride; at 100 ℃; for 0.216667h; Sealed tube; Microwave irradiation;

DOI:10.1055/s-0037-1610843

Reference yield: 82.0%

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + benzyl alcohol (100-51-6,185532-71-2) → 5,6-dichloro-2-phenyl-1H-benzo[d]imidazole (90300-22-4)

Guidance literature:

With cobalt(II) sulphate heptahydrate; lithium perchlorate; trifluoroacetic acid; In water; acetonitrile; at 20 ℃; for 2.5h; Electrochemical reaction;

DOI:10.1002/chem.201505074

upstream raw materials:

4,5-Dichloro-1,2-phenylenediamine

benzaldehyde

benzoic acid

1-phenyl-2-tosylethanone

Downstream raw materials:

9,10-dichloro-6-phenylbenzo[4,5]imidazo[2,1-a]isoquinoline

9,10-dichloro-6-(p-tolyl)benzo[4,5]imidazo[2,1-a]isoquinoline