propyl hydroxyacetate

Base Information

• Chemical Name: propyl hydroxyacetate
• CAS No.: 90357-58-7
• Molecular Formula: C5H10O3
• Molecular Weight: 118.133
• Mol file: 90357-58-7.mol

Synonyms:di-n-propyl glycolate;Propyl glycolate;Glykolsaeure-propylester;glycolic acid propyl ester;Acetic acid,hydroxy-,propyl ester;Propylglykolat;Acetic acid, hydroxy-, propyl ester;hydroxy-acetic acid,propyl ester;Oxyessigsaeurepropylester;

Chemical Property of propyl hydroxyacetate

Chemical Property:

• Vapor Pressure: 0.507mmHg at 25°C
• Refractive Index: 1.4231
• Boiling Point: 169.2oC at 760 mmHg
• Flash Point: 65.5oC
• PSA: 46.53000
• Density: 1.054g/cm3
• LogP: -0.06810
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

Propyl2-HydroxyaceticAcidEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Propyl 2-Hydroxyacetic Acid Ester is derived from Glycolic Acid (G645600), which is constituent of sugar cane jane.

Technology Process of propyl hydroxyacetate

There total 5 articles about propyl hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

propan-1-ol (71-23-8) + glycolic Acid (79-14-1) → glycolide (502-97-6) + n-propyl 2-hydroxyacetate (90357-58-7)

Guidance literature:

With toluene-4-sulfonic acid; for 10h; Reflux;

DOI:10.14233/ajchem.2013.14775

Reference yield: 84.9%

propan-1-ol (71-23-8) + glycolic Acid (79-14-1) → n-propyl 2-hydroxyacetate (90357-58-7)

Guidance literature:

With toluene-4-sulfonic acid; for 10h; Reflux;

Reference yield:

dipropyl oxalate (615-98-5) → n-propyl 2-hydroxyacetate (90357-58-7)

Guidance literature:

With hydrogen; [Ru(OAc)₂(CO)₂(PⁿBu₃)₂]; In benzene; at 180 ℃; for 144h; Product distribution;

DOI:10.1016/0022-328X(86)82019-8

upstream raw materials:

propan-1-ol

glycolic Acid

dipropyl oxalate

n-propyl chloracetate

Downstream raw materials:

Nitrooxyessigsaeurepropylester

glycolic Acid

Refernces

• 1、 Portnova,Yamshchikova, Yu. F.,Krasnykh. "Retention Characteristics and Sorption Enthalpies of Esters of Natural Hydroxycarboxylic Acids on DB-1 Stationary Phase". . p. 577 - 583. Retrieved 2019/06/03.
• 2、 Van Wouwe, Pieter,Dusselier, Michiel,Basic, Aurelie,Sels, Bert F.. "Bridging racemic lactate esters with stereoselective polylactic acid using commercial lipase catalysis". supporting information. p. 2817 - 2824. Retrieved 2013/10/08.