7-Chloro-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 7-Chloro-1,2,3,4-tetrahydroquinoline
• CAS No.: 90562-35-9
• Molecular Formula: C9H10ClN
• Molecular Weight: 167.63500
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID10516324
• Mol file: 90562-35-9.mol

Synonyms:7-Chloro-1,2,3,4-tetrahydroquinoline;90562-35-9;MFCD08544268;Quinoline, 7-chloro-1,2,3,4-tetrahydro-;7-chloro-1,2,3,4-tetrahydro-quinoline;SCHEMBL3873031;DTXSID10516324;WVEIRFXVLXAKLS-UHFFFAOYSA-N;AMY29009;VT1294;AKOS016006017;MB06330;AS-54755;SY118852;CS-0040537;FT-0708876;EN300-175050;A922425

Chemical Property of 7-Chloro-1,2,3,4-tetrahydroquinoline

Chemical Property:

• Boiling Point: 273.0±29.0 °C(Predicted)
• PKA: 4.26±0.20(Predicted)
• PSA: 12.03000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 2.83610
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 167.0501770
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

97% ^*data from raw suppliers

7-Chloro-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C=C(C=C2)Cl)NC1

Technology Process of 7-Chloro-1,2,3,4-tetrahydroquinoline

There total 9 articles about 7-Chloro-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-chloroquinoline (612-61-3) → 7-chloro-1,2,3,4-tetrahydroquinoline (90562-35-9)

Guidance literature:

With C₄₆H₄₉CoN₃P₄⁽²⁺⁾*2BF₄^(1-); hydrogen; potassium hydroxide; In isopropyl alcohol; acetonitrile; at 100 ℃; for 48h; under 22801.5 Torr; chemoselective reaction; Autoclave; Glovebox;

DOI:10.1021/jacs.9b11070

Reference yield: 98.0%

3-(2-amino-4-chlorophenyl)-propan-1-ol (1060737-02-1) → 7-chloro-1,2,3,4-tetrahydroquinoline (90562-35-9)

Guidance literature:

With C₃₀H₂₉BrMnNO₂P₂; potassium-t-butoxide; In toluene; at 135 ℃; for 24h; chemoselective reaction; Inert atmosphere; Glovebox; Sealed tube; Darkness;

DOI:10.1021/acs.organomet.2c00027

Reference yield: 91.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) → 7-chloro-1,2,3,4-tetrahydroquinoline (90562-35-9)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; boric acid; In 1,2-dichloro-ethane; at 60 ℃; for 7h; chemoselective reaction;

DOI:10.1039/c9ob02673h

upstream raw materials:

7-chloroquinoline

4,7-dichloroquinoline

6-chloro-1-indanone oxime

7-chloro-4-iodoquinoline