2-(2-phenylethyl)-1,3-benzoxazole

Base Information

• Chemical Name: 2-(2-phenylethyl)-1,3-benzoxazole
• CAS No.: 83318-25-6
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol file: 83318-25-6.mol

Synonyms:

Chemical Property of 2-(2-phenylethyl)-1,3-benzoxazole

Chemical Property:

• Vapor Pressure: 6.82E-05mmHg at 25°C
• Boiling Point: 354.5°Cat760mmHg
• Flash Point: 146.8°C
• Density: 1.156g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-phenylethyl)-1,3-benzoxazole

There total 28 articles about 2-(2-phenylethyl)-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + benzoxazole (273-53-0,29791-96-6) → 2-(β-phenylethyl)benzoxazole (83318-25-6)

Guidance literature:

With C₇₅H₇₃Br₂N₂NiO₅P; magnesium; In tetrahydrofuran; at 90 ℃; for 36h; Inert atmosphere;

Reference yield: 81.0%

2-amino-phenol (95-55-6) + 1-phenyl-propan-1-one (93-55-0) → 2-(β-phenylethyl)benzoxazole (83318-25-6)

Guidance literature:

With N-methylcyclohexylamine; sulfur; at 80 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.7b01775

Reference yield: 78.0%

2-methyl-1,3-benzoxazole (95-21-6) + benzyl alcohol (100-51-6,185532-71-2) → 2-(β-phenylethyl)benzoxazole (83318-25-6)

Guidance literature:

With [Mn(HN(C₂H₄PⁱPr₂)₂)(CO)₂Br]; potassium tert-butylate; In tert-Amyl alcohol; at 140 ℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1039/d1cc00181g

upstream raw materials:

2-methyl-1,3-benzoxazole

benzyl chloride

2-styrylbenzo[d]oxazole

2-(2-hydroxy-anilino)-4-phenyl-but-3-enenitrile

Downstream raw materials:

2-Benzooxazol-2-yl-3-phenyl-propionaldehyde

rac-2-(benzoxazol-2-yl)-1-phenylethanol

Refernces

• 1、 -. "Method of preparing benzoxazole compound". Paragraph 0085-0087; 0108. . Retrieved 2020/04/17.
• 2、 -. "Method for synthesizing 1,2-bibenzyl compound". Paragraph 0026. . Retrieved 2018/06/16.