(3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate
CAS No.:895245-30-4
Molecular Formula:C11H21NO4
Molecular Weight:231.28900
Hs Code.:
Mol file:895245-30-4.mol

Synonyms:895245-30-4;(3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3,4-bis(hydroxymethyl)-, 1,1-dimethylethylester, (3S,4S)-;(3s,4s)-1-N-Boc-3,4-Dihydroxymethylpyrrolidine;tert-butyl trans-3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate;SCHEMBL2930155;HEFYZXCUGNIOCW-IUCAKERBSA-N;tert-butyl (3S,4S)-3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate;AS-83634;CS-0079114;EN300-1221966;(3S,4S)-tert-Butyl3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate;rac-tert-butyl (3R,4R)-3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate;trans-3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester;trans-3,4-Bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(+/-)-trans-3,4-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(3S*,4S*)-3,4-Bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of (3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(3S,4S)-tert-Butyl3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate 97%
1g
$ 804.00

Alichem
(3S,4s)-tert-butyl3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate
1g
$ 844.48

Alichem
(3S,4s)-tert-butyl3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate
250mg
$ 338.00

Total 5 raw suppliers

Chemical Property of (3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：70.00000
LogP:0.39200
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:231.14705815
Heavy Atom Count:16
Complexity:237

Purity/Quality:

99% ^*data from raw suppliers

(3S,4S)-tert-Butyl3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(C(C1)CO)CO
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@H]([C@@H](C1)CO)CO
Uses (3S,4S)-tert-Butyl 3,4-Bis(hydroxymethyl)pyrrolidine-1-carboxylate is an intermediate in the preparation of pyrrolidine-?based inhibitors.

Technology Process of (3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate

There total 4 articles about (3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156469-74-8
(3S*,4S*)-1-benzyl-pyrrolidine-3,4-dicarboxylic acid diethyl ester

: 895245-30-4,1393732-25-6,895245-31-5
(3S,4S)-3,4-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol

2: lithium borohydride / tetrahydrofuran / 20 °C

3: Resolution of racemate

With lithium borohydride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 895245-30-4,1393732-25-6,895245-31-5
(3S,4S)-3,4-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol

2: lithium borohydride / tetrahydrofuran / 20 °C

3: Resolution of racemate

With lithium borohydride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;