1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-
CAS No.:911114-86-8
Molecular Formula:C35H57N3O8
Molecular Weight:647.853
Hs Code.:

1-Pyrrolidinecarboxylic acid,
3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3-
methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-,
1,1-dimethylethyl ester, (3S,4R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

There total 15 articles about 1-Pyrrolidinecarboxylic acid, 3-[[[[(2-cyclohexylethyl)amino]carbonyl]oxy]methyl]-4-[[[4-methoxy-3-(3- methoxypropoxy)benzoyl](1-methylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911114-89-1
cyclohexylmethyl-methyl-carbamoyl chloride

: 895245-25-7
(3S,4R)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 911114-86-8
(3S,4R)-3-[(cyclohexylmethyl-methyl-carbamoyloxy)-methyl]-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: (3S,4R)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

cyclohexylmethyl-methyl-carbamoyl chloride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 156469-74-8
(3S*,4S*)-1-benzyl-pyrrolidine-3,4-dicarboxylic acid diethyl ester

: 911114-86-8
(3S,4R)-3-[(cyclohexylmethyl-methyl-carbamoyloxy)-methyl]-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol

2.1: lithium borohydride / tetrahydrofuran / 20 °C

3.1: Resolution of racemate

4.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 °C

4.2: 2 h / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane; water

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5.42 h

7.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran

9.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

9.2: 20 °C

With lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 911114-86-8
(3S,4R)-3-[(cyclohexylmethyl-methyl-carbamoyloxy)-methyl]-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol

2.1: lithium borohydride / tetrahydrofuran / 20 °C

3.1: Resolution of racemate

4.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 °C

4.2: 2 h / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane; water

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5.42 h

7.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran

9.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

9.2: 20 °C

With lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane;