1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-meth ylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-meth ylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-
CAS No.:895245-25-7
Molecular Formula:C26H42N2O7
Molecular Weight:494.629
Hs Code.:

1-Pyrrolidinecarboxylic acid,
3-(hydroxymethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-meth
ylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-meth ylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

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Technology Process of 1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-meth ylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)-

There total 12 articles about 1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl](1-meth ylethyl)amino]methyl]-, 1,1-dimethylethyl ester, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 895245-26-8
(3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 895245-25-7
(3S,4R)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

: 156469-74-8
(3S*,4S*)-1-benzyl-pyrrolidine-3,4-dicarboxylic acid diethyl ester

: 895245-25-7
(3S,4R)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol

2.1: lithium borohydride / tetrahydrofuran / 20 °C

3.1: Resolution of racemate

4.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 °C

4.2: 2 h / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane; water

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5.42 h

7.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran

With lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 895245-25-7
(3S,4R)-3-hydroxymethyl-4-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol

2.1: lithium borohydride / tetrahydrofuran / 20 °C

3.1: Resolution of racemate

4.1: sodium hydride / tetrahydrofuran / 1.5 h / 0 °C

4.2: 2 h / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane; water

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 5.42 h

7.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / dichloromethane / 3 h / Heating / reflux

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran

With lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane;