5-Bromo-4-thiazolemethanol

Base Information

• Chemical Name: 5-Bromo-4-thiazolemethanol
• CAS No.: 912639-68-0
• Molecular Formula: C₄H₄BrNOS
• Molecular Weight: 194.052
• Hs Code.: 2934100090
• Mol file: 912639-68-0.mol

Synonyms:(5-bromopyrrolo[2,3-b]pyridin-1-yl)acetonitrile;(5-bromopyrimidin-2-yloxy)acetic acid;(5-bromothiazol-4-yl)-methanol;2-[(5-Bromo-2-pyrimidinyl)oxy]acetic acid;

Chemical Property of 5-Bromo-4-thiazolemethanol

Chemical Property:

• PSA: 61.36000
• LogP: 1.39790

Purity/Quality:

98%Min ^*data from raw suppliers

(5-Bromothiazol-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-4-thiazolemethanol

There total 2 articles about 5-Bromo-4-thiazolemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

5-bromothiazole-4-carboxylic acid methyl ester (913836-22-3) → (5-bromothiazol-4-yl)methanol (912639-68-0)

Guidance literature:

With methanol; lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

ethyl 5‐bromo‐1,3‐thiazole‐4‐carboxylate (61830-23-7) → (5-bromothiazol-4-yl)methanol (912639-68-0)

Guidance literature:

ethyl 5‐bromo‐1,3‐thiazole‐4‐carboxylate; With sodium tetrahydroborate; calcium chloride; In tetrahydrofuran; water; at 0 - 7 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; acetone; at 7 ℃; for 0.5h;

With sodium hydroxide; In tetrahydrofuran; water; acetone; pH=5;

upstream raw materials:

ethyl 5‐bromo‐1,3‐thiazole‐4‐carboxylate

5-bromothiazole-4-carboxylic acid methyl ester