METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97

Base Information

• Chemical Name: METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97
• CAS No.: 913836-22-3
• Molecular Formula: C5H4 Br N O2 S
• Molecular Weight: 222.062
• Hs Code.: 2934100090
• Mol file: 913836-22-3.mol

Synonyms:Methyl5-bromothiazole-4-carboxylate

Chemical Property of METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97

Chemical Property:

• Vapor Pressure: 0.00492mmHg at 25°C
• Melting Point: 98-101oC
• Boiling Point: 276℃
• PKA: -1.48±0.10(Predicted)
• Flash Point: 121℃
• PSA: 67.43000
• Density: 1.759
• LogP: 1.69220
• Storage Temp.: Keep Cold

Purity/Quality:

≥99% ^*data from raw suppliers

Methyl 5-bromo-1,3-thiazole-4-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97

There total 4 articles about METHYL 5-BROMO-1,3-THIAZOLE-4-CARBOXYLATE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + 5-bromo-1,3-thiazole-4-carboxylic acid (103878-58-6) → 5-bromothiazole-4-carboxylic acid methyl ester (913836-22-3)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 53.0%

methyl 2-amino-5-bromo-thiazole-4-carboxylate (850429-60-6) → 5-bromothiazole-4-carboxylic acid methyl ester (913836-22-3)

Guidance literature:

With tert.-butylnitrite; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

methyl 2-amino-1,3-thiazole-4-carboxylate (118452-04-3) → 5-bromothiazole-4-carboxylic acid methyl ester (913836-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: tert.-butylnitrite / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; tert.-butylnitrite; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-amino-5-bromo-thiazole-4-carboxylate

methanol

5-bromo-1,3-thiazole-4-carboxylic acid

methyl 2-amino-1,3-thiazole-4-carboxylate

Downstream raw materials:

5-isopropyl-thiazole-4-carboxylic acid methyl ester

(5-bromothiazol-4-yl)methanol

methyl 5-amino-1,3-thiazole-4-carboxylate

5-bromo-1,3-thiazole-4-carboxylic acid