4-(hidroximetil)-5-metil-1,3-dioxol-2-ona

Base Information

Chemical Name:4-(hidroximetil)-5-metil-1,3-dioxol-2-ona
CAS No.:91526-18-0
Molecular Formula:C5H6O4
Molecular Weight:130.1
Hs Code.:2932999099
European Community (EC) Number:839-946-1
DSSTox Substance ID:DTXSID10440953
Nikkaji Number:J473.782B
Wikidata:Q72485348
Mol file:91526-18-0.mol

Synonyms:4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one;

Suppliers and Price of 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
50mg
$ 60.00

SynQuest Laboratories
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 97%
5 g
$ 176.00

SynQuest Laboratories
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 97%
1 g
$ 48.00

Crysdot
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 95%
5g
$ 53.00

Crysdot
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 95%
10g
$ 89.00

Crysdot
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 95%
25g
$ 183.00

Crysdot
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 95%
100g
$ 495.00

Apolloscientific
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 96%
5g
$ 110.00

Apolloscientific
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 96%
1g
$ 30.00

Ambeed
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 96%
25g
$ 85.00

Total 138 raw suppliers

Chemical Property of 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona

Chemical Property:

Boiling Point:214℃
PKA:14.54±0.10(Predicted)
Flash Point:93℃
PSA：63.58000
Density:1.367
LogP:0.03350
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
XLogP3:-0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:130.02660867
Heavy Atom Count:9
Complexity:170

Purity/Quality:

98%min ^*data from raw suppliers

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(OC(=O)O1)CO
Description 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.
Uses 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.

Technology Process of 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona

There total 9 articles about 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 91526-17-9
4-formyloxymethyl-5-methyl-1,3-dioxolen-2-one

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

Guidance literature:: With hydrogenchloride; water; In methanol; at 20 ℃; for 1h;

Reference yield: 93.0%

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

Guidance literature:

Reference yield: 79.0%

: 80841-78-7
4-chloromethyl-5-methyl-1,3-dioxol-2-one

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

Guidance literature:: 4-chloromethyl-5-methyl-1,3-dioxol-2-one; With formic acid; triethylamine; In acetonitrile; at 10 - 65 ℃;

With hydrogenchloride; In isopropyl alcohol; Product distribution / selectivity; Reflux;