(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Base Information

Chemical Name:(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
CAS No.:912357-50-7
Molecular Formula:C₃₁H₂₄N₄O₇
Molecular Weight:564.554
Hs Code.:

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Synonyms:(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

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Chemical Property of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

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Technology Process of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

There total 8 articles about (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 147403-32-5
2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

: 912357-50-7
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Guidance literature:: 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; With dmap; potassium carbonate; p-toluenesulfonyl chloride; In N,N-dimethyl acetamide; at 10 - 20 ℃; for 3h;

With hydrogenchloride; In N,N-dimethyl acetamide; water; Product distribution / selectivity;

Reference yield:

: C₃₃H₂₁Cl₃N₄O₅

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

: 912357-50-7
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Guidance literature:: With dmap; In dichloromethane; for 12h;

Reference yield:

: 136304-78-4
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

: 912357-50-7
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-cyclopropyl-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / ethyl acetate / 6 h / 0 °C

2: hydrogenchloride / ethanol; water / 5 h / 80 °C

3: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 12.83 h / 50 - 80 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h

5: sodium hydroxide / water / 5 h / 70 °C

6: dmap; potassium carbonate; p-toluenesulfonyl chloride / N,N-dimethyl acetamide / 3 h / 10 - 20 °C

With hydrogenchloride; dmap; sodium hydroxide; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; ethyl acetate;