Chemical Property of Demethoxycurcumin
Chemical Property:
- Vapor Pressure:1.17E-13mmHg at 25°C
- Melting Point:166～170℃
- Refractive Index:1.659
- Boiling Point:571.4 °C at 760 mmHg
- PKA:8.31±0.46(Predicted)
- Flash Point:205.5 °C
- PSA：83.83000
- Density:1.282 g/cm3
- LogP:3.36130
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥10mg/mL
- XLogP3:3.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:7
- Exact Mass:338.11542367
- Heavy Atom Count:25
- Complexity:502
- Purity/Quality:
-
99%, *data from raw suppliers
Demethoxycurcumin *data from reagent suppliers
Safty Information:
- Pictogram(s):
N
- Hazard Codes:N
- Statements:
50
- Safety Statements:
61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
- Isomeric SMILES:COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC=C(C=C2)O)O
-
Uses
The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do
wn-regulation of the transcriptional coactivator p300. Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.
