6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:916764-89-1
Molecular Formula:C13H13ClN2O3
Molecular Weight:280.711
Hs Code.:
DSSTox Substance ID:DTXSID30701533
Wikidata:Q82633230
Mol file:916764-89-1.mol

Synonyms:916764-89-1;6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione;6-CHLORO-1-[(4-METHOXYPHENYL)METHYL]-3-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE;6-chloro-1-[(4-methoxyphenyl)methyl]-3-methylpyrimidine-2,4-dione;SCHEMBL4847620;DTXSID30701533;NINZAMOQCXMUNF-UHFFFAOYSA-N;BCP33932;MFCD11111307;CS-W000276;SB59895;AS-73093;W11268;6-Chloro-1-[(4-methoxyphenyl)methyl]-3-methylpyrimidine-2,4(1H,3H)-dione;6-chloro-1-[(4-methoxyphenyl)methyl]-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Suppliers and Price of 6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione 95+%
1g
$ 743.00

Crysdot
6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione 95+%
5g
$ 2232.00

Chemenu
6-Chloro-1-[(4-methoxyphenyl)methyl]-3-methyl-2,4(1H,3H)-pyrimidinedione 95%+
1g
$ 1030.00

Chemenu
6-Chloro-1-[(4-methoxyphenyl)methyl]-3-methyl-2,4(1H,3H)-pyrimidinedione 95%+
250mg
$ 558.00

Chemenu
6-Chloro-1-[(4-methoxyphenyl)methyl]-3-methyl-2,4(1H,3H)-pyrimidinedione 95%+
100mg
$ 309.00

AK Scientific
6-CHLORO-1-[(4-METHOXYPHENYL)METHYL]-3-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE
250mg
$ 646.40

Total 8 raw suppliers

Chemical Property of 6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Chemical Property:

Boiling Point:398.7±52.0 °C(Predicted)
PKA:-3?+-.0.40(Predicted)
PSA：53.23000
Density:1.37±0.1 g/cm3(Predicted)
LogP:1.25730
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:280.0614700
Heavy Atom Count:19
Complexity:403

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)C=C(N(C1=O)CC2=CC=C(C=C2)OC)Cl

Technology Process of 6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

There total 2 articles about 6-Chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 4318-56-3
3-methyl-6-chlorouracil

: 824-94-2
p-methoxybenzyl chloride

: 916764-89-1
6-chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

: 2565-47-1
1-methyl-2,4,6-pyrimidinetrione

: 916764-89-1
6-chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 5 h / 0 - 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;