5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

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Chemical Name:5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
CAS No.:960064-67-9
Molecular Formula:C₂₄H₂₀N₆O₂
Molecular Weight:424.462
Hs Code.:

Synonyms:5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

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Chemical Property of 5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

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Technology Process of 5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

There total 5 articles about 5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 7-(4-methoxybenzyl)-5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

: 960064-67-9
5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Guidance literature:: 7-(4-methoxybenzyl)-5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione; With aluminum (III) chloride; In methoxybenzene; 1,2-dichloro-ethane; at 20 ℃;

With water; In methoxybenzene; 1,2-dichloro-ethane;

Reference yield:

: 4318-56-3
3-methyl-6-chlorouracil

: 960064-67-9
5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

2: hydrazine / ethanol; methanol / 3 h / Inert atmosphere; Reflux

3: N,N-dimethyl-formamide / 72 h / 115 °C / Inert atmosphere

4: potassium carbonate / acetone / 20 °C / Inert atmosphere

5: trifluoroacetic acid; trifluorormethanesulfonic acid / 25 °C / Inert atmosphere

With trifluorormethanesulfonic acid; potassium carbonate; trifluoroacetic acid; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

: 916764-89-1
6-chloro-1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione

: 960064-67-9
5-methyl-3-(phenylamino)-2-(4-(pyridin-2-yl)benzyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine / ethanol; methanol / 3 h / Inert atmosphere; Reflux

2: N,N-dimethyl-formamide / 72 h / 115 °C / Inert atmosphere

3: potassium carbonate / acetone / 20 °C / Inert atmosphere

4: trifluoroacetic acid; trifluorormethanesulfonic acid / 25 °C / Inert atmosphere

With trifluorormethanesulfonic acid; potassium carbonate; trifluoroacetic acid; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.jmedchem.5b01751