(+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester

Base Information

Chemical Name:(+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester
CAS No.:930120-95-9
Molecular Formula:C₂₈H₄₀O₂SSi
Molecular Weight:468.776
Hs Code.:

Synonyms:(+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester

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Chemical Property of (+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester

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Technology Process of (+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester

There total 9 articles about (+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917590-73-9
(E)-4-(tert-butyl-diphenyl-silanyloxy)-but-2-enethioic acid S-ethyl ester

: 930120-95-9
(+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

1.2: 95 percent / various solvent(s); diethyl ether / 17 h / -75 °C

2.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

3.1: 1.491 g / CH₂Cl₂ / 24 h / Heating

4.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

4.2: 90 percent / various solvent(s); diethyl ether / 17 h / -75 °C

5.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

6.1: 214 mg / CH₂Cl₂ / 24 h / Heating

With triethylsilane; palladium on activated charcoal; (S,R_Fe)-Josiphos*CuBr; In diethyl ether; dichloromethane;
DOI:10.1039/b612593j

Reference yield:

: 917590-87-5
(R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-thiobutyric acid S-ethyl ester

: 930120-95-9
(+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

2.1: 1.491 g / CH₂Cl₂ / 24 h / Heating

3.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

3.2: 90 percent / various solvent(s); diethyl ether / 17 h / -75 °C

4.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

5.1: 214 mg / CH₂Cl₂ / 24 h / Heating

With triethylsilane; palladium on activated charcoal; (S,R_Fe)-Josiphos*CuBr; In diethyl ether; dichloromethane;
DOI:10.1039/b612593j

Reference yield:

: 930120-92-6
(+)-(E)-(R)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enethioic acid S-ethyl ester

: 930120-95-9
(+)-(E)-(5R,7R)-8-(tert-butyl-diphenyl-silanyloxy)-5,7-dimethyl-oct-2-enethioic acid S-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

1.2: 90 percent / various solvent(s); diethyl ether / 17 h / -75 °C

2.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

3.1: 214 mg / CH₂Cl₂ / 24 h / Heating

With triethylsilane; palladium on activated charcoal; (S,R_Fe)-Josiphos*CuBr; In diethyl ether; dichloromethane;
DOI:10.1039/b612593j