Technology Process of Propanedioic acid,
2-[6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methylenehexyl]-, 1,3-diethyl
ester
There total 4 articles about Propanedioic acid,
2-[6-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methylenehexyl]-, 1,3-diethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl malonate;
With
sodium hydride;
In
tetrahydrofuran;
cooling;
acetic acid 2-[4-(tert-butyldiphenylsilanyloxy)butyl]allyl ester;
[Pd(triphenylphosphine)(allyl)(chloride)];
In
tetrahydrofuran;
for 48h;
Heating;
DOI:10.1016/j.tet.2006.09.022
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 80 percent / Jones reagent / benzene / 20 °C
2.1: butyllithium / tetrahydrofuran / -78 - 0 °C
2.2: 65 percent / tetrahydrofuran / 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran / cooling
3.2: 68 percent / Pd(allyl)(PPh3)Cl / tetrahydrofuran / 48 h / Heating
With
n-butyllithium; jones reagent; sodium hydride;
In
tetrahydrofuran; benzene;
1.1: Jones oxidation / 2.2: Wittig olefination;
DOI:10.1016/j.tet.2006.09.022
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: butyllithium / tetrahydrofuran / -78 - 0 °C
1.2: 65 percent / tetrahydrofuran / 1 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / cooling
2.2: 68 percent / Pd(allyl)(PPh3)Cl / tetrahydrofuran / 48 h / Heating
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran;
1.2: Wittig olefination;
DOI:10.1016/j.tet.2006.09.022
![acetic acid 2-[4-(tert-butyldiphenylsilanyloxy)butyl]allyl ester](/Databaselist/images/loading.webp)
