N-(2-chloro-3-pyridinyl)phenylamide

Base Information

• Chemical Name: N-(2-chloro-3-pyridinyl)phenylamide
• CAS No.: 91813-32-0
• Molecular Formula: C12H9ClN2O
• Molecular Weight: 232.669
• Mol file: 91813-32-0.mol

Synonyms:

Chemical Property of N-(2-chloro-3-pyridinyl)phenylamide

Chemical Property:

• Melting Point: 82-83 °C
• Boiling Point: 292.4±25.0 °C (760 mmHg)
• PSA: 41.99000
• Density: 1.341±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.06030

Purity/Quality:

97% ^*data from raw suppliers

N-(2-CHLOROPYRIDIN-3-YL)BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-chloro-3-pyridinyl)phenylamide

There total 7 articles about N-(2-chloro-3-pyridinyl)phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-3-aminopyridine (6298-19-7) + benzoyl chloride (98-88-4) → N-(2-chloro-3-pyridinyl)phenylamide (91813-32-0)

Guidance literature:

In pyridine; 1. -10 deg C 2. 15h r. t.;

Reference yield: 79.0%

2-chloro-3-aminopyridine (6298-19-7) + benzoic acid (65-85-0,8013-63-6) → N-(2-chloro-3-pyridinyl)phenylamide (91813-32-0)

Guidance literature:

With pyridine; 1,3,5-trichloro-2,4,6-triazine; In acetonitrile; at 140 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1055/s-0036-1589472

Reference yield: 55.0%

2-chloro-3-aminopyridine (6298-19-7) + phenyl formate (1864-94-4) → N-(2-chloro-3-pyridinyl)phenylamide (91813-32-0)

Guidance literature:

With Nonafluorobutanesulfonyl fluoride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; In acetonitrile; at 80 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201311198

upstream raw materials:

2-chloro-3-aminopyridine

benzoic acid ethyl ester

benzoyl chloride

vinyl benzoate

Downstream raw materials:

N-(6-Butyryl-2-chloro-pyridin-3-yl)-benzamide

N-(4-Butyryl-2-chloro-pyridin-3-yl)-benzamide

2-phenyloxazolo<5,4-b>pyridine

2-phenyl thiazolo<5,4-b>pyridine

Refernces

• 1、 Li, Haoquan,Neumann, Helfried,Beller, Matthias,Wu, Xiao-Feng. "Aryl formate as bifunctional reagent: Applications in palladium-catalyzed carbonylative coupling reactions using in situ generated CO". supporting information. p. 3183 - 3186. Retrieved 2014/04/03.
• 2、 Xu, Dan,Xu, Xianfang,Liu, Zongliang,Sun, Li-Ping,You, Qidong. "A general and efficient synthesis of 2-substituted oxazolopyridines". scheme or table. p. 1172 - 1174. Retrieved 2009/08/09.