N-{[(Quinolin-3-yl)methoxy]carbonyl}-L-tyrosine

Base Information

Chemical Name:N-{[(Quinolin-3-yl)methoxy]carbonyl}-L-tyrosine
CAS No.:918440-77-4
Molecular Formula:C20H18N2O5
Molecular Weight:366.373
Hs Code.:
DSSTox Substance ID:DTXSID00582452
Wikidata:Q82473887

Synonyms:918440-77-4;N-{[(Quinolin-3-yl)methoxy]carbonyl}-L-tyrosine;DTXSID00582452

Suppliers and Price of N-{[(Quinolin-3-yl)methoxy]carbonyl}-L-tyrosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-{[(Quinolin-3-yl)methoxy]carbonyl}-L-tyrosine

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:366.12157168
Heavy Atom Count:27
Complexity:507

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=C(C=N2)COC(=O)NC(CC3=CC=C(C=C3)O)C(=O)O
Isomeric SMILES:C1=CC=C2C(=C1)C=C(C=N2)COC(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)O

Technology Process of N-{[(Quinolin-3-yl)methoxy]carbonyl}-L-tyrosine

There total 4 articles about N-{[(Quinolin-3-yl)methoxy]carbonyl}-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-hydroxy-phenyl)-2-(quinolin-3-ylmethoxycarbonylamino)-propionic acid methyl ester

: 918440-77-4
3-(4-hydroxy-phenyl)-2-(quinolin-3-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; for 3h;
DOI:10.1021/jm060839a

Reference yield:

: 918440-74-1
4-nitrophenyl (quinolin-3-ylmethyl) carbonate

: 918440-77-4
3-(4-hydroxy-phenyl)-2-(quinolin-3-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide

2: aq. LiOH / tetrahydrofuran; methanol / 3 h

With lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm060839a

Reference yield:

: 13669-42-6
3-quinolylcarboxaldehyde

: 918440-77-4
3-(4-hydroxy-phenyl)-2-(quinolin-3-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / tetrahydrofuran; ethanol / cooling

2: 219 mg / N-methylmorpholine / 7 h / 20 °C / cooling

3: dimethylformamide

4: aq. LiOH / tetrahydrofuran; methanol / 3 h

With 4-methyl-morpholine; lithium hydroxide; lithium borohydride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm060839a