Quinolin-3-yl-methanol

Base Information

• Chemical Name: Quinolin-3-yl-methanol
• CAS No.: 13669-51-7
• Molecular Formula: C10H9 N O
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• Mol file: 13669-51-7.mol

Synonyms:(3-Quinolyl)methanol;1H-1,3-(Epoxymethano)quinoline; 3-(Hydroxymethyl)quinoline;Quinolin-3-ylmethanol

Chemical Property of Quinolin-3-yl-methanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 65-67 °C
• Refractive Index: 1.667
• Boiling Point: 329.784°C at 760 mmHg
• PKA: 13.68±0.10(Predicted)
• Flash Point: 153.248°C
• PSA: 33.12000
• Density: 1.219g/cm³
• LogP: 1.72710
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Quinolin-3-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinolin-3-yl-methanol

There total 17 articles about Quinolin-3-yl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-quinolylcarboxaldehyde (13669-42-6) → 3-Hydroxymethylquinoline (13669-51-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃;

DOI:10.1021/jo00306a009

Reference yield: 92.0%

2-chloro-3-(hydroxymethyl)quinoline (125917-60-4) → 3-Hydroxymethylquinoline (13669-51-7)

Guidance literature:

With sodium tetrahydroborate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.01.053

Reference yield: 86.0%

2,6-dichloroquinoline-3-carbaldehyde (73568-41-9) → 3-Hydroxymethylquinoline (13669-51-7)

Guidance literature:

With hydrogen; sodium acetate; palladium dichloride; In methanol; at 35 ℃; for 2h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2012.05.054

upstream raw materials:

3-quinolylcarboxaldehyde

ethyl 3-quinolinecarboxylate

quinoline-3-carboxylic acid

(2-iodoquinolin-3-yl)methanol

Downstream raw materials:

3-(chloromethyl)-quinoline

3-(bromomethyl)quinoline

4-nitrophenyl (quinolin-3-ylmethyl) carbonate

2-fluoro-6-(quinolin-3-ylmethoxy)benzonitrile

Refernces

• 1、 Zhu, Longfei,Ye, Sen,Wang, Jing,Zhu, Jiazheng,He, Guangke,Liu, Xiang. "Supported Iridium Catalyst for Clean Transfer Hydrogenation of Aldehydes and Ketones using Methanol as Hydrogen Source". . . Retrieved 2022/02/01.
• 2、 Aleku, Godwin A.,Leys, David,Roberts, George W.. "Biocatalytic reduction of α,β-unsaturated carboxylic acids to allylic alcohols". supporting information. p. 3927 - 3939. Retrieved 2020/07/09.