Levotofisopam

Base Information

• Chemical Name: Levotofisopam
• CAS No.: 82059-51-6
• Deprecated CAS: 1232900-89-8
• Molecular Formula: C22H26N2O4
• Molecular Weight: 382.459
• UNII: 11ZYL7QK34
• Nikkaji Number: J2.362.969K
• Wikidata: Q27251353
• NCI Thesaurus Code: C76535
• ChEMBL ID: CHEMBL2107351
• Mol file: 82059-51-6.mol

Synonyms:1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine;dextofisopam;EGYT-341;Grandaxin;levotofisopam;tofisopam;tofizopam

Chemical Property of Levotofisopam

Chemical Property:

• PSA: 61.64000
• LogP: 3.31270
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 382.18925731
• Heavy Atom Count: 28
• Complexity: 579

Purity/Quality:

≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1C(=NN=C(C2=CC(=C(C=C12)OC)OC)C3=CC(=C(C=C3)OC)OC)C
• Isomeric SMILES: CC[C@@H]1C(=NN=C(C2=CC(=C(C=C12)OC)OC)C3=CC(=C(C=C3)OC)OC)C
• Recent ClinicalTrials: Study of Levotofisopam 50 mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout
• Uses: Anxiolytic, autonomic instability.

Technology Process of Levotofisopam

There total 3 articles about Levotofisopam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tofisopam (22345-47-7,914303-48-3,914303-49-4,914303-50-7,914303-51-8) → (+)-Tofisopam (82059-50-5) + (-)-Tofisopam (82059-51-6)

Guidance literature:

In acetonitrile; at 22 ℃; for 0.025 - 0.1h; Purification / work up;

Reference yield:

→ (+)-Tofisopam (82059-50-5) + (-)-Tofisopam (82059-51-6)

Guidance literature:

With tofisopam; In methanol; acetonitrile; at 25 ℃; Purification / work up;

Reference yield:

→ (-)-Tofisopam (82059-51-6)

Guidance literature:

In acetonitrile; Purification / work up;

upstream raw materials:

tofisopam

Downstream raw materials:

C₂₂H₂₅⁽²⁾HN₂O₄

tofisopam

C₄H₆O₆*C₂₂H₂₆N₂O₄

Refernces

• 1、 -. "USE OF TOFISOPAM AS A PDE10A INHIBITOR". Page/Page column 16-17. . Retrieved 2008/06/13.
• 2、 -. "Conversion process for 2,3-benzodiazepine enantiomers". Page/Page column 2. . Retrieved 2008/06/13.