DEXTOFISOPAM,(R)-(5R)-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-7,8-DIMETHOXY-4-METHYL-5H-2,3-BENZODIAZEPINE

Base Information

• Chemical Name: DEXTOFISOPAM,(R)-(5R)-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-7,8-DIMETHOXY-4-METHYL-5H-2,3-BENZODIAZEPINE
• CAS No.: 82059-50-5
• Molecular Formula: C22H26N2O4
• Molecular Weight: 382.459
• Mol file: 82059-50-5.mol

Synonyms:(R)-1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-hydroxy-8-methoxy-5H-2,3-benzo-diazepine;R-Tofisopam;Dextofisopam;(R)-1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine;(R)-1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine;(+)-Tofisopam;Dextofisopam [USAN:INN];

Chemical Property of DEXTOFISOPAM,(R)-(5R)-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-7,8-DIMETHOXY-4-METHYL-5H-2,3-BENZODIAZEPINE

Chemical Property:

• Vapor Pressure: 7.13E-09mmHg at 25°C
• Boiling Point: 479°Cat760mmHg
• Flash Point: 195.2°C
• PSA: 61.64000
• Density: 1.15g/cm³
• LogP: 3.31270

Purity/Quality:

≥98% ^*data from raw suppliers

DEXTOFISOPAM 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Treatment of irritable bowel syndrome, Crohn’s disease; anti-anxiety, anti-stress.

Technology Process of DEXTOFISOPAM,(R)-(5R)-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-7,8-DIMETHOXY-4-METHYL-5H-2,3-BENZODIAZEPINE

There total 4 articles about DEXTOFISOPAM,(R)-(5R)-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-7,8-DIMETHOXY-4-METHYL-5H-2,3-BENZODIAZEPINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tofisopam (22345-47-7,914303-48-3,914303-49-4,914303-50-7,914303-51-8) → (+)-Tofisopam (82059-50-5)

Guidance literature:

In methanol; acetonitrile; at 25 ℃; Purification / work up;

Reference yield:

tofisopam (22345-47-7,914303-48-3,914303-49-4,914303-50-7,914303-51-8) → (+)-Tofisopam (82059-50-5) + (-)-Tofisopam (82059-51-6)

Guidance literature:

In acetonitrile; at 22 ℃; for 0.025 - 0.1h; Purification / work up;

Reference yield:

→ (+)-Tofisopam (82059-50-5) + (-)-Tofisopam (82059-51-6)

Guidance literature:

With tofisopam; In methanol; acetonitrile; at 25 ℃; Purification / work up;

upstream raw materials:

tofisopam