9-[5-o-Acetyl-2,3-o-(1-methylethylidene)pentofuranosyl]-8-bromo-9h-purin-6-amine

Base Information

Chemical Name:9-[5-o-Acetyl-2,3-o-(1-methylethylidene)pentofuranosyl]-8-bromo-9h-purin-6-amine
CAS No.:13089-46-8
Molecular Formula:C15H18BrN5O5
Molecular Weight:428.2379
Hs Code.:
NSC Number:109513
DSSTox Substance ID:DTXSID70926960

Synonyms:13089-46-8;NSC109513;9-[5-o-acetyl-2,3-o-(1-methylethylidene)pentofuranosyl]-8-bromo-9h-purin-6-amine;DTXSID70926960;NSC-109513

Suppliers and Price of 9-[5-o-Acetyl-2,3-o-(1-methylethylidene)pentofuranosyl]-8-bromo-9h-purin-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 9-[5-o-Acetyl-2,3-o-(1-methylethylidene)pentofuranosyl]-8-bromo-9h-purin-6-amine

Chemical Property:

Vapor Pressure:1.34E-14mmHg at 25°C
Boiling Point:605.3°Cat760mmHg
Flash Point:319.9°C
Density:1.94g/cm³
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:427.04913
Heavy Atom Count:26
Complexity:569

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OCC1C2C(C(O1)N3C4=NC=NC(=C4N=C3Br)N)OC(O2)(C)C

Technology Process of 9-[5-o-Acetyl-2,3-o-(1-methylethylidene)pentofuranosyl]-8-bromo-9h-purin-6-amine

There total 4 articles about 9-[5-o-Acetyl-2,3-o-(1-methylethylidene)pentofuranosyl]-8-bromo-9h-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 13089-45-7
8-bromo-2',3'-O-isopropylene adenosine

: 13089-46-8
5'-O-acetyl-8-bromo-2',3'-O-(1-methylethylidene)adenosine

Guidance literature:: With pyridine; at 60 ℃;
DOI:10.1016/j.tet.2007.02.053

Reference yield:

: 2946-39-6
8-bromoadenosine

: 13089-46-8
5'-O-acetyl-8-bromo-2',3'-O-(1-methylethylidene)adenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 30 h / 20 °C

2: 95 percent / pyridine / 60 °C

With pyridine; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.02.053

Reference yield:

: 58-61-7
adenosine

: 13089-46-8
5'-O-acetyl-8-bromo-2',3'-O-(1-methylethylidene)adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / sodium acetate; acetic acid; bromine / H₂O / 4 h / 20 °C

2: 61 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 30 h / 20 °C

3: 95 percent / pyridine / 60 °C

With pyridine; bromine; sodium acetate; toluene-4-sulfonic acid; acetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.02.053