N-(5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzamide

Base Information

Chemical Name:N-(5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzamide
CAS No.:918662-94-9
Molecular Formula:C17H18N6O
Molecular Weight:322.37
Hs Code.:
DSSTox Substance ID:DTXSID20582151
Wikidata:Q82473484

Synonyms:918662-94-9;N-(5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzamide;N-[5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzamide;DTXSID20582151

Suppliers and Price of N-(5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzamide

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:322.15420922
Heavy Atom Count:24
Complexity:475

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=NC=C(C(=N2)NC(=O)C3=CC=CC=C3)C#N

Technology Process of N-(5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzamide

There total 4 articles about N-(5-Cyano-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 103151-40-2
4-amino-2-(4-methyl-piperazin-1-yl)-pyrimidine-5-carbonitrile

: 918662-94-9
N-[5-cyano-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-benzamide

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1080/00397910600773726

Reference yield:

: 109-01-3
1-methyl-piperazine

: 918662-94-9
N-[5-cyano-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / Heating

2: t-BuOK / dimethylformamide / 0 - 20 °C

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1080/00397910600773726

Reference yield:

: 770-30-9
4-amino-2-(methylthio)pyrimidine-5-carbonitrile

: 918662-94-9
N-[5-cyano-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: m-chloroperbenzoic acid / tetrahydrofuran / 0 - 20 °C

2: tetrahydrofuran / Heating

3: t-BuOK / dimethylformamide / 0 - 20 °C

With potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1080/00397910600773726